Evidence map›Paper›PMID 33129280›Full record

ArticleEnvironmental health and preventive medicine2020

Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).

Toshiharu Ninomiya, Shigeyuki Nakaji, Tetsuya Maeda, Masahito Yamada, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi, Tomoyuki Ohara, Jun Hata and 14 more

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In one paragraph

Article in Environmental health and preventive medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. nino@eph.med.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0003-1345-9032
Shigeyuki NakajiDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Tetsuya MaedaDivision of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
Masahito YamadaDepartment of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Kenji NakashimaNational Hospital Organization, Matsue Medical Center, Matsue, Japan.
Takaaki MoriDepartment of Neuropsychiatry, Neuroscience Ehime University Graduate School of Medicine, Ehime, Japan.
Minoru TakebayashiDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Tomoyuki OharaDepartment of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Jun HataDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yoshihiro KokuboDepartment of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Kazuhiro UchidaDepartment of Health Promotion, School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.
Yasuyuki TakiDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Shuzo KumagaiKumagai Institute of Health Policy, Fukuoka, Japan.
Koji YonemotoDivision of Biostatistics, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Japan.
Hisako YoshidaDepartment of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kaori MutoDepartment of Public Policy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Saitama, Japan.
Masato AkiyamaDepartment of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Michiaki KuboHisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
Manabu IkedaDepartment of Psychiatry, Osaka University Medical School, Suita, Japan.
Shigenobu KanbaDepartment of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Yutaka KiyoharaHisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
JPSFC-AD Study Group

Funding

Japan Agency for Medical Research and Development JP20dk0207025
6 · The paper itself

Abstract

backgroundThe burden of dementia is growing rapidly and has become a medical and social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors and the etiology of dementia. We aimed to perform a large-scale dementia cohort study to elucidate environmental and genetic risk factors for dementia, as well as their interaction.

methodsThe Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a multisite, population-based prospective cohort study of dementia, which was designed to enroll approximately 10,000 community-dwelling residents aged 65 years or older from 8 sites in Japan and to follow them up prospectively for at least 5 years. Baseline exposure data, including lifestyles, medical information, diets, physical activities, blood pressure, cognitive function, blood test, brain magnetic resonance imaging (MRI), and DNA samples, were collected with a pre-specified protocol and standardized measurement methods. The primary outcome was the development of dementia and its subtypes. The diagnosis of dementia was adjudicated by an endpoint adjudication committee using standard criteria and clinical information according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Revised Edition. For brain MRI, three-dimensional acquisition of T1-weighted images was performed. Individual participant data were pooled for data analyses.

resultsThe baseline survey was conducted from 2016 to 2018. The follow-up surveys are ongoing. A total of 11,410 individuals aged 65 years or older participated in the study. The mean age was 74.4 years, and 41.9% were male. The prevalence of dementia at baseline was 8.5% in overall participants. However, it was 16.4% among three sites where additional home visit and/or nursing home visit surveys were performed. Approximately two-thirds of dementia cases at baseline were Alzheimer's disease.

conclusionsThe prospective cohort data from the JPSC-AD will provide valuable insights regarding the risk factors and etiology of dementia as well as for the development of predictive models and diagnostic markers for the future onset of dementia. The findings of this study will improve our understanding of dementia and provide helpful information to establish effective preventive strategies for dementia in Japan.

Indexed as

AgedAlzheimer DiseaseDementiaEnvironmentFemaleHumansIncidenceJapanMaleMiddle AgedPrevalenceProspective StudiesRisk FactorsAlzheimer’s diseaseDementiaProspective cohort study

Identifiers

PMID33129280
PMCPMC7603740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.