Evidence map›Paper›PMID 33129230›Full record

ArticleInternational journal of cancer2021

Quality diet indexes and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study.

Hung N Luu, Nithya Neelakantan, Ting-Ting Geng, Renwei Wang, George Boon-Bee Goh, Jose C Clemente, Aizhen Jin, Rob M van Dam, Wei Jia, Jaideep Behari and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Hung N LuuDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, UPMC Cancer Pavilion, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2172-1849
Nithya NeelakantanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Ting-Ting GengSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Renwei WangDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, UPMC Cancer Pavilion, Pittsburgh, Pennsylvania, USA.
George Boon-Bee GohHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Jose C ClementeIcahn Institute for Genomics & Multiscale Biology, Department of Genetics and Genomic Sciences, and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Aizhen JinHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Wei JiaUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Jaideep BehariDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Woon-Puay KohSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, UPMC Cancer Pavilion, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4620-3108
National University of Singapore · SGUniversity of Pittsburgh · USDuke-NUS Medical School · SGHarvard University · USIcahn School of Medicine at Mount Sinai · USSingapore General Hospital · SGUniversity of Hawaiʻi at Mānoa · USUniversity of Pittsburgh Medical Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA144034NCI NIH HHS UM1 CA182876NIDDK NIH HHS P30 DK120531NIH HHS R01 CA144034NIH HHS UM1 CA182876
6 · The paper itself

Abstract

There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternative Health Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (aMED), Dietary Approaches to Stop Hypertension (DASH) and Heathy Diet Indicator (HDI). We identified 561 incident HCC cases among the cohort participants after a mean of 17.6 years of follow-up. Cox proportional hazard regression model was used to estimate hazard ratio (HR) and 95% confidence interval (CI) for HCC in relation to these DQI scores. Unconditional logistic regression method was used to evaluate the associations between DQIs and HCC risk among a subset of individuals who tested negative for hepatitis B surface antigen (HBsAg). High scores of AHEI-2010, aMED and DASH, representing higher dietary quality, were associated with lower risk of HCC (all P

Indexed as

AgedCarcinoma, HepatocellularChinaDiet SurveysHealth SurveysHumansLiver NeoplasmsMiddle AgedRisk FactorsSingaporediet-quality index (DQI) scoreshepatocellular carcinomarisk factor

Identifiers

PMID33129230
PMCPMC11572543
OpenAlexW3094783111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.