Evidence map›Paper›PMID 33129141›Full record

ArticleMedical image analysis2021

Dual-branch combination network (DCN): Towards accurate diagnosis and lesion segmentation of COVID-19 using CT images.

Kai Gao, Jianpo Su, Zhongbiao Jiang, Ling-Li Zeng, Zhichao Feng, Hui Shen, Pengfei Rong, Xin Xu, Jian Qin, Yuexiang Yang and 2 more

Abstract readComparative Study
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Role of Artificial Intelligence in COVID-19 Detection.Sensors (Basel, Switzerland) · 2021
    Pooled it
  3. Performance of AI Approaches for COVID-19 Diagnosis Using Chest CT Scans: The Impact of Architecture and Dataset.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Artificial Intelligence and Infectious Disease Imaging.The Journal of infectious diseases · 2023
    Article
  18. Article
  19. Article
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kai GaoCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Jianpo SuCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Zhongbiao JiangDepartment of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ling-Li ZengCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Zhichao FengDepartment of Radiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hui ShenCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China. Electronic address: shenhui@nudt.edu.cn.
Pengfei RongDepartment of Radiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: rongpengfei66@163.com.
Xin XuCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Jian QinCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Yuexiang YangCollege of Computer Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
Wei WangDepartment of Radiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dewen HuCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent global outbreak and spread of coronavirus disease (COVID-19) makes it an imperative to develop accurate and efficient diagnostic tools for the disease as medical resources are getting increasingly constrained. Artificial intelligence (AI)-aided tools have exhibited desirable potential; for example, chest computed tomography (CT) has been demonstrated to play a major role in the diagnosis and evaluation of COVID-19. However, developing a CT-based AI diagnostic system for the disease detection has faced considerable challenges, which is mainly due to the lack of adequate manually-delineated samples for training, as well as the requirement of sufficient sensitivity to subtle lesions in the early infection stages. In this study, we developed a dual-branch combination network (DCN) for COVID-19 diagnosis that can simultaneously achieve individual-level classification and lesion segmentation. To focus the classification branch more intensively on the lesion areas, a novel lesion attention module was developed to integrate the intermediate segmentation results. Furthermore, to manage the potential influence of different imaging parameters from individual facilities, a slice probability mapping method was proposed to learn the transformation from slice-level to individual-level classification. We conducted experiments on a large dataset of 1202 subjects from ten institutes in China. The results demonstrated that 1) the proposed DCN attained a classification accuracy of 96.74% on the internal dataset and 92.87% on the external validation dataset, thereby outperforming other models; 2) DCN obtained comparable performance with fewer samples and exhibited higher sensitivity, especially in subtle lesion detection; and 3) DCN provided good interpretability on the loci of infection compared to other deep models due to its classification guided by high-level semantic information. An online CT-based diagnostic platform for COVID-19 derived from our proposed framework is now available.

Indexed as

Neural Networks, ComputerTomography, X-Ray ComputedCOVID-19HumansPneumonia, ViralRadiography, ThoracicSARS-CoV-2Sensitivity and SpecificityAttentionCombined segmentation and classificationCOVID-19CT image

Identifiers

PMID33129141
PMCPMC7543739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.