ArticleBiosensors & bioelectronics2021
Long period grating in double cladding fiber coated with graphene oxide as high-performance optical platform for biosensing.
Article in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 137 citations in OpenAlex.
- Evanescent wave-based optical biosensors for innovations, medical application and future perspectives.Journal of advanced research · 2026Review
- Graphene Oxide-Functionalized Optical Sensor for Label-Free Detection of Breast Cancer Cells.ACS applied nano materials · 2025Article
- Enhanced Sensitivity Mach-Zehnder Interferometer-Based Tapered-in-Tapered Fiber-Optic Biosensor for the Immunoassay of C-Reactive Protein.Biosensors · 2025Article
- Ultrasensitive and selective impedance paper-based analytical device through Dual-C imprinted sensor for determination of carcinoembryonic antigen and C-reactive protein.Mikrochimica acta · 2025Article
- C-reactive protein (CRP) evaluation in human urine using optical sensor supported by machine learning.Scientific reports · 2024Article
- Unpacking the packaged optical fiber bio-sensors: understanding the obstacle for biomedical application.Frontiers in bioengineering and biotechnology · 2024Review
- Rapid detection of vaccinia virus using biofunctionalized fiber-optic ball-tip biosensors.Scientific reports · 2023Article
- Fiber Laser-Based Lasso-Shaped Biosensor for High Precision Detection of Cancer Biomarker-CEACAM5 in Serum.Biosensors · 2023Article
- Article
- Innovative Photonic Sensors for Safety and Security, Part III: Environment, Agriculture and Soil Monitoring.Sensors (Basel, Switzerland) · 2023Review
- Innovative Photonic Sensors for Safety and Security, Part I: Fundamentals, Infrastructural and Ground Transportations.Sensors (Basel, Switzerland) · 2023Review
- Innovative Photonic Sensors for Safety and Security, Part II: Aerospace and Submarine Applications.Sensors (Basel, Switzerland) · 2023Review
- Advancement in COVID-19 detection using nanomaterial-based biosensors.Exploration (Beijing, China) · 2023Review
- Long-Period Fiber Grating Sensors for Chemical and Biomedical Applications.Sensors (Basel, Switzerland) · 2023Review
- Review
- Label-free optical biosensors in the pandemic era.Nanophotonics (Berlin, Germany) · 2022Review
- Progress on Optical Fiber Biochemical Sensors Based on Graphene.Micromachines · 2022Review
- Portable electrochemical micro-workstation platform for simultaneous detection of multiple Alzheimer's disease biomarkers.Mikrochimica acta · 2022Article
- All Fiber-Optic Immunosensors Based on Elliptical Core Helical Intermediate-Period Fiber Grating with Low-Sensitivity to Environmental Disturbances.Biosensors · 2022Article
- Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures.Biomedicines · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, the development and testing of a novel fiber-optic based label-free biosensor is presented, whose performance were verified through the detection of C-reactive protein (CRP) in serum. The device is based on a long period grating fabricated in a double cladding fiber with a W-shaped refractive index (RI) profile. As a result, the working point of the device was tuned to the mode transition region by chemical etching of the outer fiber cladding, obtaining a significant enhancement of the RI sensitivity and an excellent visibility of the grating resonances due to the mode transition in an all-silica structure. The fiber transducer was coated with a nanometric thin layer of graphene oxide in order to provide functional groups for the covalent immobilization of the biological recognition element. A very low limit of detection of about 0.15 ng/mL was obtained during the detection of CRP in serum, and a large working range (1 ng/mL - 100 μg/mL) of clinical relevance has been also achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.