Evidence map›Paper›PMID 33128939›Full record

Trial reportJournal of affective disorders2021

Rare Functional Variants Associated with Antidepressant Remission in Mexican-Americans: Short title: Antidepressant remission and pharmacogenetics in Mexican-Americans.

Ma-Li Wong, Mauricio Arcos-Burgos, Sha Liu, Alice W Licinio, Chenglong Yu, Eunice W M Chin, Wei-Dong Yao, Xin-Yun Lu, Stefan R Bornstein, Julio Licinio

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00265291 (Antidepressant Treatment of Mexican-Americans), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00265291 phase2completednot on this map

Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group

TypeinterventionalSponsorNational Institute of General Medical Sciences (NIGMS)Ran1999 to 2008Enrolled700ConditionsMajor Depressive Disorder, Major Depression, Unipolar DepressionArmsfluoxetine or desipramine
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ma-Li WongDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University, Syracuse, NY, USA; Department of Neuroscience and Physiology, State University of New York, Upstate Medical University, Syracuse, NY, USA; Mind & Brain Theme, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia; Department of Psychiatry, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia. Electronic address: wongma@upstate.edu.
Mauricio Arcos-BurgosGrupo de Investigación en Psiquiatría, Departamento de Psiquiatría, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin, Antioquia, Colombia.
Sha LiuMind & Brain Theme, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia.
Alice W LicinioMind & Brain Theme, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia.
Chenglong YuMind & Brain Theme, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia; Department of Psychiatry, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia.
Eunice W M ChinDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University, Syracuse, NY, USA.
Wei-Dong YaoDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University, Syracuse, NY, USA; Department of Neuroscience and Physiology, State University of New York, Upstate Medical University, Syracuse, NY, USA.
Xin-Yun LuDepartment of Neuroscience & Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Stefan R BornsteinMedical Clinic III, Carl Gustav Carus University Hospital, Dresden University of Technology, Dresden, Germany.
Julio LicinioDepartment of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University, Syracuse, NY, USA; Department of Neuroscience and Physiology, State University of New York, Upstate Medical University, Syracuse, NY, USA; Mind & Brain Theme, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia; Department of Psychiatry, Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia. Electronic address: licinioJ@upstate.edu.

Funding

UCLA PHARMACOGENETICS &PHARMACOGENOMICS RESEARCH GROUPU01GM061394 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LICINIO, JULIO · 2000 to 2005
$4.7M
Nonproteolytic Polyubiquitin Chains at the SynapseR01MH106489 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI YAO, WEI-DONG · 2015 to 2019
$2.1M
NIGMS NIH HHS U01 GM061394NIMH NIH HHS R01 MH106489
6 · The paper itself

Abstract

introductionRare genetic functional variants can contribute to 30-40% of functional variability in genes relevant to drug action. Therefore, we investigated the role of rare functional variants in antidepressant response.

methodMexican-American individuals meeting the Diagnostic and Statistical Manual-IV criteria for major depressive disorder (MDD) participated in a prospective randomized, double-blind study with desipramine or fluoxetine. The rare variant analysis was performed using whole-exome genotyping data. Network and pathway analyses were carried out with the list of significant genes.

resultsThe Kernel-Based Adaptive Cluster method identified functional rare variants in 35 genes significantly associated with treatment remission (False discovery rate, FDR <0.01). Pathway analysis of these genes supports the involvement of the following gene ontology processes: olfactory/sensory transduction, regulation of response to cytokine stimulus, and meiotic cell cycleprocess. LIMITATIONS: Our study did not have a placebo arm. We were not able to use antidepressant blood level as a covariate. Our study is based on a small sample size of only 65 Mexican-American individuals. Further studies using larger cohorts are warranted.

conclusionOur data identified several rare functional variants in antidepressant drug response in MDD patients. These have the potential to serve as genetic markers for predicting drug response.

trial registrationClinicalTrials.gov NCT00265291.

Indexed as

Major Depressive DisorderAntidepressive AgentsDouble-Blind MethodHumansMexican AmericansPharmacogeneticsProspective StudiesTreatment OutcomeAntidepressive AgentsAntidepressantsDepressionDrug responseHispanicPharmacogenomicsWhole-exome genotyping

Identifiers

PMID33128939
PMCPMC7953425

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.