ArticleMolecular biology reports2020
Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The Role of MUC1 in Gastric Cancer Development.Cancers · 2025Review
- The association between PSCA gene polymorphism and hepatocellular carcinoma risk.World journal of surgical oncology · 2025Article
- Pan-cancer analysis of PSCA that is associated with immune infiltration and affects patient prognosis.PloS one · 2024Article
- Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly.Scientific reports · 2023Article
- An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- Article
- Contribution of Interleukin-4 Promoter Genotypes to Gastric Cancer Risk in Taiwan.In vivo (Athens, Greece)Article
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
Genetic variants are considered risk factors for gastric cancer. To date, 61 polymorphisms have been identified as associated with this disease. The aim of the present study was to analyze the association of some of those polymorphisms with GC in Chile. We performed a case-control study including 310 gastric cancer cases and 311 controls to assess the association of 36 single-nucleotide polymorphisms genotyped by Global Screening Array (GSA). Three polymorphisms was significantly associated: PSCA rs2294008 (allele model, OR = 1.49, 95%CI 1.17-1.88, P = 1.08 × 10-3), IL-4 rs2243250 (allele model, OR = 1.28, 95%CI 1.01-1.62, P = 0.04), and MUC1 rs4072037 (allele model, OR = 0.78, 95%CI 0.61-0.99, P = 0.04).PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in Chile. It suggests that those polymorphisms could be used as biomarkers to assess the genetic risk for this cancer outside of the previously studied populations, not only for East Asians and Caucasians populations.
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