Evidence map›Paper›PMID 33128582›Full record

ArticleCurrent genetics2021

Participation of the HIM1 gene of yeast Saccharomyces cerevisiae in the error-free branch of post-replicative repair and role Polη in him1-dependent mutagenesis.

E A Alekseeva, T A Evstyukhina, V T Peshekhonov, V G Korolev

Open access · hybridAbstract read
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Article in Current genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

E A AlekseevaDivision of Molecular and Radiation Biophysics, Laboratory of Eukaryote Genetics, Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, Kurchatov Institute, mkr. Orlova Roscha 1, 188300, Gatchina, Russia. alekseeva_ea@pnpi.nrcki.ru.ORCID http://orcid.org/0000-0002-9660-9042
T A EvstyukhinaDivision of Molecular and Radiation Biophysics, Laboratory of Eukaryote Genetics, Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, Kurchatov Institute, mkr. Orlova Roscha 1, 188300, Gatchina, Russia.
V T PeshekhonovDivision of Molecular and Radiation Biophysics, Laboratory of Eukaryote Genetics, Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, Kurchatov Institute, mkr. Orlova Roscha 1, 188300, Gatchina, Russia.
V G KorolevDivision of Molecular and Radiation Biophysics, Laboratory of Eukaryote Genetics, Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, Kurchatov Institute, mkr. Orlova Roscha 1, 188300, Gatchina, Russia.
Kurchatov Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In eukaryotes, DNA damage tolerance (DDT) is determined by two repair pathways, homologous repair recombination (HRR) and a pathway controlled by the RAD6-epistatic group of genes. Monoubiquitylation of PCNA mediates an error-prone pathway, whereas polyubiquitylation stimulates an error-free pathway. The error-free pathway involves components of recombination repair; however, the factors that act in this pathway remain largely unknown. Here, we report that the HIM1 gene participates in error-free DDT. Notably, inactivation RAD30 gene encoding Polη completely suppresses him1-dependent UV mutagenesis. Furthermore, data obtained show a significant role of Polη in him1-dependent mutagenesis, especially at non-bipyrimidine sites (NBP sites). We demonstrate that him1 mutation significantly reduces the efficiency of the induction expression of RNR genes after UV irradiation. Besides, this paper presents evidence that significant increase in the dNTP levels suppress him1-dependent mutagenesis. Our findings show that Polη responsible for him1-dependent mutagenesis.

Indexed as

DNA DamageDNA-Directed DNA PolymeraseDNA RepairDNA ReplicationEpistasis, GeneticMutagenesisRecombinational DNA RepairSaccharomyces cerevisiae ProteinsUbiquitin-Conjugating EnzymesY-Family DNA PolymerasesDNA-Directed DNA PolymeraseHIM1 protein, S cerevisiaeRad30 proteinRAD6 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitin-Conjugating EnzymesY-Family DNA PolymerasesDNA damageHIM1 geneMutagenesisPost-replication repairYeast

Identifiers

PMID33128582
PMCPMC7886746
OpenAlexW3094861028

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.