ArticleNeuromodulation : journal of the International Neuromodulation Society2021
Optimizing Deep Brain Stimulation Parameters in Obsessive-Compulsive Disorder.
Article in Neuromodulation : journal of the International Neuromodulation Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Predictors of deep brain stimulation response in patients with obsessive compulsive disorder: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Deep brain stimulation for obsessive-compulsive-disorder: a systematic review and meta-analysis of individual participant outcome data from sham-controlled trials.Molecular psychiatry · 2025Pooled it
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Psychedelics and neurostimulation for treatment resistant psychiatric disorders.Discover mental health · 2026Review
- Towards Closed-Loop Neuromodulation for Type 2 Diabetes With Ex Vivo Validation of Beta-Cell Activity and FOPP Detection.IEEE transactions on biomedical circuits and systems · 2026Article
- Deep Brain Stimulation for the Treatment of Treatment-Resistant Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Clinical Trials in 106 Patients.The Psychiatric quarterly · 2026Review
- Incidental resolution of pedophilia in a patient undergoing deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD): a case report and long-term follow-up.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement.bioRxiv : the preprint server for biology · 2025Article
- AI-Driven Multimodal Brain-State Decoding for Personalized Closed-Loop TENS: A Comprehensive Review.Brain sciences · 2025Review
- Mechanisms of DBS: from informational lesions to circuit modulation and implications in OCD.Frontiers in human neuroscience · 2025Review
- Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation.Scientific reports · 2024Article
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites.Biological psychiatry · 2024Article
- Clinical outcomes of deep brain stimulation for obsessive-compulsive disorder: Insight as a predictor of symptom changes.Psychiatry and clinical neurosciences · 2024Article
- Telemedicine in patients with obsessive-compulsive disorder after deep brain stimulation: a case series.Frontiers in human neuroscience · 2024Article
- Closed-loop neurostimulation for the treatment of psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Phenomenological Changes Associated with Deep Brain Stimulation for Obsessive Compulsive Disorder: A Cognitive Appraisal Model of Recovery.Brain sciences · 2023Article
- Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model.Nature communications · 2023Article
- Article
- Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control.Brain : a journal of neurology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectivesDeep brain stimulation (DBS) is an innovative and effective treatment for patients with therapy-refractory obsessive-compulsive disorder (OCD). DBS offers unique opportunities for personalized care, but no guidelines on how to choose effective and safe stimulation parameters in patients with OCD are available. Our group gained relevant practical knowledge on DBS optimization by treating more than 80 OCD patients since 2005, the world's largest cohort. The article's objective is to share this experience. MATERIALS AND
methodsWe provide guiding principles for optimizing DBS stimulation parameters in OCD and discuss the neurobiological and clinical basis.
resultsAdjustments in stimulation parameters are performed in a fixed order. First, electrode contact activation is determined by the position of the electrodes on postoperative imaging. Second, voltage and pulse width are increased stepwise, enlarging both the chance of symptom reduction and of inducing side effects. Clinical evaluation of adjustments in stimulation parameters needs to take into account: 1) the particular temporal sequence in which the various OCD symptoms and DBS side-effects change; 2) the lack of robust response predictors; 3) the limited sensitivity of the Yale-Brown Obsessive-Compulsive Scale to assess DBS-induced changes in OCD symptoms; and 4) a patient's fitness for additional cognitive-behavioral therapy (CBT).
conclusionsDecision-making in stimulation parameter optimization needs to be sensitive to the particular time-courses on which various symptoms and side effects change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.