Evidence map›Paper›PMID 33128351›Full record

ArticleBrain and behavior2021

The Danish Multiple Sclerosis Registry.

Melinda Magyari, Hanna Joensen, Bjarne Laursen, Nils Koch-Henriksen

Abstract read
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Big data in multiple sclerosis.Current opinion in neurology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melinda MagyariDepartment of Neurology, The Danish Multiple Sclerosis Registry, Rigshospitalet, Glostrup, Denmark.ORCID 0000-0002-0972-5222
Hanna JoensenDepartment of Neurology, The Danish Multiple Sclerosis Registry, Rigshospitalet, Glostrup, Denmark.
Bjarne LaursenNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Nils Koch-HenriksenDepartment of Neurology, The Danish Multiple Sclerosis Registry, Rigshospitalet, Glostrup, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe Danish Multiple Sclerosis Registry is the oldest operative and nationwide MS registry. We present The Danish Multiple Sclerosis Registry with its history, data collection, scientific contribution, and national and international research collaboration. MATERIALS AND

methodsDetailed description of data collection, completeness, quality optimizing procedures, funding, and legal, ethical and data protection issues are provided.

resultsThe total number of registered cases with clinical isolated syndrome and multiple sclerosis since 1956 was by start of May 2020 30,023 of whom 16,515 cases were alive and residing in Denmark, giving a prevalence rate of about 284 per 100,000 population. The mean annual number of new cases receiving an MS diagnosis was 649 per year in the period 2010 to 2019. In total, 7,945 patients (48.1%) are receiving disease modifying therapy at the start of May 2020.

conclusionsMultiple Sclerosis registers are becoming increasingly important, not only for epidemiological research but also by quantifying the burden of the disease for the patients and society and helping health care providers and regulators in their decisions. The Danish Multiple Sclerosis Registry has served as data source for a number of scientific publications including epidemiological studies on changes in incidence and mortality, cohort studies investigating risk factors for developing MS, comorbidities and socioeconomic outcomes in the MS population, and observational studies on effectiveness of disease modifying treatments outside the narrow realms of randomized clinical trials.

Indexed as

Multiple SclerosisDenmarkHumansIncidencePrevalenceRegistriesdata sourceepidemiologymultiple sclerosisobservational studiesreal world dataregistry

Identifiers

PMID33128351
PMCPMC7821574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.