Evidence map›Paper›PMID 33128246›Full record

GuidelineInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2021

FIGO/ICM guidelines for preventing Rhesus disease: A call to action.

Gerard H A Visser, Trude Thommesen, Gian Carlo Di Renzo, Anwar H Nassar, Steven L Spitalnik, FIGO Committee for Safe Motherhood, Newborn Health

Registry-linked trialAbstract readPractice Guideline
In one paragraph

Guideline in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07107477 (Prospective Randomized Controlled Trial to Evaluate if Tailored Antibiotic and Steroid Therapy Based on the Interleukin-6), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07107477 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Prospective Randomized Controlled Trial to Evaluate if Tailored Antibiotic and Steroid Therapy Based on the Interleukin-6 (IL-6) Value in Amniotic Fluid Obtained by Amniocentesis in Patients With Premature Rupture of Membranes is Associated With Pregnancy Prolongation Compared to Standard Management.

TypeinterventionalSponsorThe Central and Eastern European Gynecologic Oncology GroupRan2025 to 2028Enrolled138ConditionsPreterm Premature Rupture of Membranes (PPROM)ArmsTailored antibiotic and steroid therapy based on the IL-6 value in amniotic fluid obtained by amniocentesis in patients with premature rupture of membranes, Antenatal steroids administration, Neuroprotection, antibiotic prophylaxis, Antibiotics administration
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Rhesus testing and anti-D prophylaxis in RhD-negative women undergoing first-trimester abortion-Systematic Review and Opinion.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
  2. Prevention of RhD alloimmunization in the first trimester of pregnancy: Clinical practice guidelines of the French College of Obstetricians and Gynecologists.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gerard H A VisserInternational Federation of Gynecology and Obstetrics, London, UK.
Trude ThommesenWorldwide Initiative for Rh Disease Eradication, New York, NY, USA.
Gian Carlo Di RenzoWorldwide Initiative for Rh Disease Eradication, New York, NY, USA.
Anwar H NassarInternational Federation of Gynecology and Obstetrics, London, UK.
Steven L SpitalnikWorldwide Initiative for Rh Disease Eradication, New York, NY, USA.
FIGO Committee for Safe Motherhood, Newborn Health

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The introduction of anti-Rh(D) immunoglobulin more than 50 years ago has resulted in only a 50% decrease in Rhesus disease globally owing to a low uptake of this prophylactic approach. The International Federation of Gynecology and Obstetrics, International Confederation of Midwives, and Worldwide Initiative for Rhesus Disease Eradication have reviewed current evidence regarding the utility of anti-Rh(D) immunoglobulin. Taking into account the effectiveness anti-Rh(D), the new guidelines propose adjusting the dose for different indications and prioritizing its administration by indication.

Indexed as

FemaleHumansPregnancyRh IsoimmunizationRho(D) Immune GlobulinRHO(D) antibodyRho(D) Immune GlobulinAnti-D immunoglobulinFIGOGuidelinesInternational Confederation of MidwivesProphylaxisRhesus diseaseWorldwide Initiative for Rhesus Disease Eradication

Identifiers

PMID33128246
PMCPMC7898700

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.