ArticleEuropean journal of epidemiology2021
Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies.
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Article in European journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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39citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 6% of its field
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity's influence on breast cancer risk.Science advances · 2026Pooled it
- Obesity and Risk of Pre- and Postmenopausal Breast Cancer in Africa: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- How does weight gain since the age of 18 years affect breast cancer risk in later life? A meta-analysis.Breast cancer research : BCR · 2024Pooled it
- Adiposity and risk of breast cancer in 280 000 Chinese women: a prospective cohort study.International journal of epidemiology · 2026Observational
- Adverse childhood experiences, adult adiposity, and risk of young-onset breast cancer subtypes in a population-based case-control study.Cancer causes & control : CCC · 2026Article
- Targeting metabolic dysregulation in postmenopausal breast cancer: Synergistic effects of nutrition-based interventions and exercise on molecular and cellular pathways.Cancer cell international · 2026Review
- Overall and central adiposity and risk of contralateral breast cancer: The California Breast Cancer Survivorship Consortium.International journal of cancer · 2026Article
- Recent Advances (2020-2025) in Estrogen and ER-Positive Breast Cancer: Receptor Signaling, Tumor Microenvironment, Endocrine Therapy Resistance and Innovative Treatment Strategies-A Comprehensive Review.Cancer management and research · 2026Review
- The aetiology of breast cancer subtypes: results from the Million Women Study.Breast cancer research : BCR · 2025Article
- Observational
- Factors influencing traditional adiposity indicators and mammary adipocyte size in women with breast cancer.International journal of obesity (2005) · 2025Article
- Anthropometry and the Risk of Breast Cancer in Moroccan Women: A Large Multicentric Case-Control Study.Current oncology (Toronto, Ont.) · 2025Article
- Hormone-associated dietary patterns and premenopausal breast cancer risk.Breast cancer research and treatment · 2025Article
- Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts.Breast cancer research : BCR · 2025Article
- Adiposity throughout Adulthood and Risk of Young-Onset Breast Cancer Tumor Subtypes in the Young Women's Health History Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Risk factors for breast cancer subtypes by race and ethnicity: a scoping review.Journal of the National Cancer Institute · 2024Article
- Height and breast cancer risk in premenopausal Korean women aged under 40 years of age.British journal of cancer · 2024Article
- Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies.Breast cancer research : BCR · 2024Article
- Mortality Prediction Modeling for Patients with Breast Cancer Based on Explainable Machine Learning.Cancers · 2024Article
Corrections and comments
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Authors and funding
42 authors at 20 institutions in 8 countries.
Piet A van den BrandtDepartment of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands. PA.vandenBrandt@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0001-8781-8099
Regina G ZieglerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Molin WangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tao HouDepartment of Nutrition, Harvard T.H Chan School of Public Health, Boston, MA, USA.
Ruifeng LiDepartment of Nutrition, Harvard T.H Chan School of Public Health, Boston, MA, USA.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Claudia AgnoliEpidemiology and Prevention Unit, Department of Research, Fondazione Istituto Nazionale Tumori, 20133, Milan, Italy.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Yu ChenDivision of Epidemiology, Department of Population Health and Department of Environmental Medicine, New York University School of Medicine, New York, USA.
Avonne E ConnorDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jeanine M GenkingerDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Gretchen GierachDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Gary G GoodmanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Niclas HåkanssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Vittorio KroghEpidemiology and Prevention Unit, Department of Research, Fondazione Istituto Nazionale Tumori, 20133, Milan, Italy.
Loic Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
M Elena MartinezDepartment of Family Medicine and Public Health School of Medicine, University of California San Diego, La Jolla, CA, USA.
Anthony B MillerDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alpa V PatelEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Anna PrizmentDivision of Hematology, Oncology and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA.
Kim RobienDepartment of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Thomas E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, USA.
Norie SawadaEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Leo J SchoutenDepartment of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Shoichiro TsuganeEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Kami K WhiteCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Walter C WillettDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Alicja WolkUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Anne Zeleniuch-JacquotteDivision of Epidemiology, Department of Population Health and Department of Environmental Medicine, New York University School of Medicine, New York, USA.
Stephanie A Smith-WarnerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USNational Institutes of Health · USAmerican Cancer Society · USBrigham and Women's Hospital · USFondazione IRCCS Istituto Nazionale dei Tumori · ITFred Hutch Cancer Center · USJohns Hopkins University · USMaastricht University · NLNew York University · USThe University of Melbourne · AUUniversity of Hawaiʻi at Mānoa · USAlbert Einstein College of Medicine · USCentre international de recherche sur le cancer · FRCity of Hope · USColumbia University Irving Medical Center · USKarolinska Institutet · SEMilken Institute · USUniversity of California San Diego · USUniversity of Minnesota · USUniversity of Oslo · NO
Funding
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MProspective Studies of Diet and Cancer in the AARP CohortZIACP010196 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SINHA, RASHMI · 2009 to 2025
$21.0MWomen's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MThe NYU Women's Health StudyU01CA182934 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, YU · 2020 to 2023
$2.7MNCI NIH HHS P30 CA071789NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA182913NCI NIH HHS U01 CA182934NCI NIH HHS UM1 CA186107World Health Organization 001
Abstract
Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. Associations between prediagnostic anthropometric factors and risk of premenopausal and postmenopausal BC overall and ER/PR status subtypes were investigated in a pooled analysis of 20 prospective cohorts, including 36,297 BC cases among 1,061,915 women, using multivariable Cox regression analyses, controlling for reproductive factors, diet and other risk factors. We estimated dose-response relationships and tested for nonlinear associations using restricted cubic splines. Height showed positive, linear associations for premenopausal and postmenopausal BC risk (6-7% RR increase per 5 cm increment), with stronger associations for receptor-positive subtypes. Body mass index (BMI) at cohort baseline was strongly inversely associated with premenopausal BC risk, and strongly positively-and nonlinearly-associated with postmenopausal BC (especially among women who never used hormone replacement therapy). This was primarily observed for receptor-positive subtypes. Early adult BMI (at 18-20 years) showed inverse, linear associations for premenopausal and postmenopausal BC risk (21% and 11% RR decrease per 5 kg/m
Indexed as
Weight GainAdultAgedBody Mass IndexBody WeightBreast NeoplasmsCohort StudiesFemaleHumansMenopauseMiddle AgedPremenopauseProspective StudiesReceptors, EstrogenRisk FactorsReceptors, EstrogenBody heightBody weightBreast neoplasmsCohort studiesEstrogen receptorWeight change
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