Evidence map›Paper›PMID 33128179›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2021

Non-invasive hemodynamic determination of patient-specific optimal pacing mode in cardiac resynchronization therapy.

Virginie Ferchaud, Rodrigue Garcia, Nicolas Bidegain, Bruno Degand, Paul Milliez, Théo Pezel, Ghassan Moubarak

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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03779802 (Comparison of the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03779802 naterminatednot on this map

Comparison of the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization.

TypeinterventionalSponsorCMC Ambroise ParéRan2019 to 2020Enrolled50ConditionsHeart Failure, Cardiac Resynchronization TherapyArmsDevice programming of ABBOTT CRT pacemaker or defibrillator
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Virginie FerchaudDepartment of Electrophysiology and Pacing, Centre Médico-Chirurgical Ambroise Paré, 27 Boulevard Victor Hugo, 92200, Neuilly-sur-Seine, France.
Rodrigue GarciaDepartment of Cardiology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Nicolas BidegainDepartment of Cardiology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Bruno DegandDepartment of Cardiology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Paul MilliezDepartment of Cardiology, Centre Hospitalier Universitaire de Caen Normandie, Caen, France.
Théo PezelDepartment of Cardiology, Centre Hospitalier Universitaire Lariboisière, Paris, France.
Ghassan MoubarakDepartment of Electrophysiology and Pacing, Centre Médico-Chirurgical Ambroise Paré, 27 Boulevard Victor Hugo, 92200, Neuilly-sur-Seine, France. gmoubarak@rythmologie.paris.ORCID http://orcid.org/0000-0002-8345-0845

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCardiac resynchronization therapy (CRT) devices have multiple programmable pacing parameters. The purpose of this study was to determine the best pacing mode, i.e., associated with the greatest acute hemodynamic response, in each patient.

methodsPatients in sinus rhythm and intact atrioventricular conduction were included within 3 months of implantation of devices featuring SyncAV and multipoint pacing (MPP) algorithms. The effect of nominal biventricular pacing using the latest activated electrode (BiV-Late), optimized atrioventricular delay (AVD), nominal and optimized SyncAV, and anatomical MPP was determined by non-invasive measurement of systolic blood pressure (SBP). CRT response was defined as SBP increase > 10% relative to baseline.

resultsThirty patients with left bundle branch block (LBBB) were included. BiV-Late increased SBP compared to intrinsic rhythm (128 ± 21 mmHg vs. 121 ± 22 mmHg, p = 0.0002). The best pacing mode further increased SBP to 140 ± 19 mmHg (p < 0.0001 vs. BiV-Late). The proportion of CRT responders increased from 40% with BiV-Late to 80% with the best pacing mode (p = 0.0005). Compared to BiV-Late, optimized AVD and optimized SyncAV increased SBP (to 134 ± 21 mmHg, p = 0.004, and 133 ± 20 mmHg, p = 0.0003, respectively), but nominal SyncAV and MPP did not. The best pacing mode was variable between patients and was different from nominal BiV-Late in 28 (93%) patients. Optimized AVD was the most frequent best mode, in 14 (47%) patients.

conclusionIn patients with LBBB, the best pacing mode was patient-specific and doubled the magnitude of acute hemodynamic response and the proportion of acute CRT responders compared to nominal BiV-Late pacing.

trial registrationClinicalTrials.gov : NCT03779802.

Indexed as

Cardiac Resynchronization TherapyHeart FailureBundle-Branch BlockCardiac Resynchronization Therapy DevicesHemodynamicsHumansTreatment OutcomeAcute hemodynamic responseAtrioventricular delayCardiac resynchronization therapyMultipoint pacingPacing algorithmSyncAV

Identifiers

PMID33128179

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.