Evidence map›Paper›PMID 33128155›Full record

ArticleThe international journal of cardiovascular imaging2021

Clinically isolated aortitis: imaging features and clinical outcomes: comparison with giant cell arteritis and giant cell aortitis.

Ayaz Aghayev, Camden P Bay, Sara Tedeschi, Paul A Monach, Umberto Campia, Marie Gerhard-Herman, Michael L Steigner, Richard N Mitchell, William P Docken, Marcelo DiCarli

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Coral reef aorta in a child: a case report.Journal of medical case reports · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Localized Forms of Vasculitis.Current rheumatology reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ayaz AghayevCardiovascular Imaging Program, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. aaghayev@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-6092-7065
Camden P BayDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sara TedeschiDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Paul A MonachDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Umberto CampiaDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marie Gerhard-HermanDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michael L SteignerCardiovascular Imaging Program, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Richard N MitchellDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
William P DockenDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marcelo DiCarliCardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) describe imaging features of CIA, (2) compare dilation rate and wall thickening of aortic aneurysms in patients with CIA versus those with giant cell arteritis/aortitis (GCA), (3) present clinical outcomes of CIA patients. Retrospective search of electronic records from 2004 to 2018 yielded 71 patients, 52 of whom were female, with a mean age of 67.5 ± 9.0 years old, with a new clinical diagnosis of cranial or extracranial GCA (GCA group), and giant cell aortitis revealed by the aortic biopsy (CIA group). Comparisons between groups were conducted using the Wilcoxon rank-sum and Fisher's exact tests. Survival from the date of initial diagnosis to the end of data collection was compared between the two groups through a log-rank test. CIA patients (n = 23; 32%) presented with cardiovascular symptoms, and none had systemic inflammatory symptoms. Inflammatory markers were significantly higher among GCA patients than among CIA patients (p < 0.0001). The CIA group demonstrated thoracic aortic aneurysms without wall thickening. None of the GCA patients (n = 48; 68%) had aneurysmal dilation in the aorta at the time of diagnosis. None of the four CIA patients had FDG uptake in the aorta, while nine out of 13 GCA patients had FDG uptake in the vessels. There was no statistically significant difference in the survival between the two groups (p = 0.12). CIA patients presented with cardiovascular symptoms and was characterized by aneurysm of the aorta without the involvement of the infrarenal aortic segment. The role of FDG-PET/CT in CIA is less certain, though none of the patients in this cohort had FDG uptake in the vessels.

Indexed as

AortographyAdrenal Cortex HormonesAgedAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsAortic AneurysmAortitisComputed Tomography AngiographyDiagnosis, DifferentialDilatation, PathologicDisease ProgressionFemaleFluorodeoxyglucose F18Giant Cell ArteritisHumansMagnetic Resonance AngiographyAdrenal Cortex HormonesAntibodies, Monoclonal, HumanizedAnti-Inflammatory AgentsFluorodeoxyglucose F18RadiopharmaceuticalstocilizumabClinically isolated aortitisComputed tomography angiographyFDG-PET/CTGiant cell arteritisMagnetic resonance angiography

Identifiers

PMID33128155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.