ArticleProceedings of the National Academy of Sciences of the United States of America2020
First-in-class humanized FSH blocking antibody targets bone and fat.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
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44 citing papers in PubMed, 54 citations in OpenAlex.
- The extragonadal biology of gonadotropin hormones: should we rename these?Endocrine connections · 2026Article
- From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.Bone research · 2026Review
- Neuroendocrine and neural control of bone mass in health and disease.The Journal of clinical investigation · 2026Review
- Fshr gene depletion prevents recognition memory loss, fat accrual and bone loss in Alzheimer's mice.Molecular psychiatry · 2026Article
- The influence of hormonal changes during pregnancy on bone metabolism - a mini review.Frontiers in endocrinology · 2026Review
- Targeting FSH for osteoporosis, obesity, and Alzheimer's disease.Trends in molecular medicine · 2025Review
- Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy.Nature communications · 2025Article
- Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models.The Journal of clinical investigation · 2025Article
- Higher FSH Level Is Associated With Increased Risk of Incident Hip Fracture in Older Adults, Independent of Sex Hormones.The Journal of clinical endocrinology and metabolism · 2025Article
- Gene-dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer's mice.Molecular psychiatry · 2025Article
- From hormones to neurodegeneration: how FSH drives Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue.Molecular medicine (Cambridge, Mass.) · 2024Article
- Pharmacological inhibition of HIF2 protects against bone loss in an experimental model of estrogen deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuroendocrinology of bone.Pituitary · 2024Review
- FSH, bone, belly and brain.The Journal of endocrinology · 2024Review
- Understanding osteokine biology.Cell metabolism · 2024Article
- Gene-Dose-Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer's Mice.Research square · 2024Article
- Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health.Current osteoporosis reports · 2024Review
- Pituitary crosstalk with bone, adipose tissue and brain.Nature reviews. Endocrinology · 2023Review
- Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR.International journal of molecular sciences · 2023Article
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Authors and funding
36 authors at 7 institutions in 3 countries.
Sakshi GeraThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-1615-6259
Damini SantThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Shozeb HaiderDepartment of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, WC1N 1AX London, United Kingdom.ORCID 0000-0003-2650-2925
Funda KorkmazThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Tan-Chun KuoThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Mehr MathewThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Helena Perez-PenaDepartment of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, WC1N 1AX London, United Kingdom.
Honglin XieGenScript Biotech Corporation, Piscataway, NJ 08854.
Hao ChenMolecular Imaging Program at Stanford, Bio-X Program, Department of Radiology, Stanford University, Stanford, CA 94305.
Rogerio BatistaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Kejun MaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Zhen ChengMolecular Imaging Program at Stanford, Bio-X Program, Department of Radiology, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8177-9463
Elina HadeliaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Cemre RobinsonThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Anne MacdonaldThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Sari MiyashitaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Anthony WilliamsThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Gregory JebianThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Hirotaka MiyashitaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Anisa GumerovaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Kseniia IevlevaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-0177-234X
Pinar SmithThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Jiahuan HeDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-2965-3331
Vitaly RyuThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Victoria DeMambroCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074.
Matthew A QuinnDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27157.ORCID 0000-0002-3528-6569
Marcia MeseckTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-9527-6602
Se-Min KimThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
T Rajendra KumarDepartment of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO 80045.
Jameel IqbalThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Maria I NewDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029 maria.new@mssm.edu mone.zaidi@mssm.edu.
Daria LiznevaThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Clifford J RosenCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074.ORCID 0000-0003-3436-8199
Aaron J HsuehDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305.
Tony YuenThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Mone ZaidiThe Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029; maria.new@mssm.edu mone.zaidi@mssm.edu.
Icahn School of Medicine at Mount Sinai · USStanford University · USMaine Medical Center Research Institute · USUniversity College London · GBLanzhou University Second Hospital · CNUniversity of Colorado Denver · USWake Forest University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTargeting FSH for the Therapy of Osteoporosis, Obesity and NeurodegenerationU19AG060917 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PENG LIU · 2019 to 2026
$29.0MThyrotropin Receptor, Thyrotropin and Mechanisms of Bone LossR01DK113627 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVIES, TERRY FRANCIS, IQBAL, JAMEEL Z · 2017 to 2020
$2.8MNCATS NIH HHS UL1 TR001863NIA NIH HHS U19 AG060917NIDDK NIH HHS R01 DK113627
Abstract
Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, structure, and function of a first-in-class, fully humanized, epitope-specific FSH blocking antibody with a
Indexed as
EpitopesAdipose TissueAnimalsAntibodies, BlockingAntibodies, MonoclonalBone and BonesBone DensityFemaleFollicle Stimulating HormoneFollicle Stimulating Hormone, beta SubunitHumansHypercholesterolemiaMiceMice, Inbred C57BLMolecular Dynamics SimulationObesityAntibodies, BlockingAntibodies, MonoclonalEpitopesFollicle Stimulating HormoneFollicle Stimulating Hormone, beta SubunitReceptors, FSHadiposefollicle-stimulating hormonehumanizationmonoclonal antibody
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