Evidence map›Paper›PMID 33127643›Full record

ReviewThe Journal of biological chemistry2020

Structure, mechanism, and regulation of mitochondrial DNA transcription initiation.

Urmimala Basu, Alicia M Bostwick, Kalyan Das, Kristin E Dittenhafer-Reed, Smita S Patel

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
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  9. Mitoepigenetic Alterations in Early-Onset Parkinson's Disease.International journal of molecular sciences · 2026
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Urmimala BasuDepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA; Graduate School of Biomedical Sciences, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Alicia M BostwickDepartment of Chemistry, Hope College, Holland, Michigan, USA.
Kalyan DasDepartment of Microbiology, Immunology, and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Kristin E Dittenhafer-ReedDepartment of Chemistry, Hope College, Holland, Michigan, USA. Electronic address: dittenhaferreed@hope.edu.
Smita S PatelDepartment of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA. Electronic address: patelss@rutgers.edu.
Hope College · USRutgers, The State University of New Jersey · USRega Institute for Medical Research · BE

Funding

Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity.R35GM118086 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SMITA S PATEL · 2016 to 2026
$8.9M
NIGMS NIH HHS R35 GM118086
6 · The paper itself

Abstract

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular functions and serve as centers of metabolite processing, cellular signaling, and apoptosis. To accomplish these roles, mitochondria rely on the genetic information in their small genome (mitochondrial DNA) and the nucleus. A growing appreciation for mitochondria's role in a myriad of human diseases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fueled the study of biochemical mechanisms that control mitochondrial function. The mitochondrial transcriptional machinery is different from nuclear machinery. The

Indexed as

Gene Expression RegulationTranscription, GeneticTranscription Initiation SiteDNA, MitochondrialHumansMitochondrial ProteinsTranscription FactorsDNA, MitochondrialMitochondrial ProteinsTranscription FactorsDNA transcriptionenzyme mechanismenzyme structurehuman mitochondrial RNA polymerasemitochondriamitochondrial DNA (mtDNA)mitochondrial DNA transcriptionmitochondrial gene regulationRNA polymerasestructure-functiontranscriptiontranscription initiation factorstranscription regulationyeast mitochondrial RNA polymerase

Identifiers

PMID33127643
PMCPMC7939475
OpenAlexW3095939538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.