ArticleScience immunology2020
Persistent STAT5 activation reprograms the epigenetic landscape in CD4
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Strategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions.Science China. Life sciences · 2026Pooled it
- From barrier to trigger: leveraging tumor hypoxia for precise control of CAR-T cell activity.Molecular biology reports · 2026Review
- Precision Immunoregulation in transplantation: The rise of engineered Treg therapies.Molecular biology reports · 2026Review
- SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.EMBO reports · 2026Article
- Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans.JCI insight · 2026Article
- Characterization of a Cytokine-Independent STAT5 Activator.Biomedicines · 2026Article
- Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements.Journal of advanced research · 2026Review
- Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes.Signal transduction and targeted therapy · 2026Article
- Asymmetry and redundancy of STAT5 paralogs across CD8Communications biology · 2026Article
- SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.bioRxiv : the preprint server for biology · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control.bioRxiv : the preprint server for biology · 2025Article
- Article
- CDK4/6 Inhibitor Priming Enhances PD-1 Blockade via SellAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An engineered viral protein activates STAT5 to prevent T cell suppression.Science immunology · 2025Article
- Cytokines in Focus: IL-2 and IL-15 in NK Adoptive Cell Cancer Immunotherapy.Immune network · 2025Review
- Role of CD4Journal of translational medicine · 2025Review
- Supercharging CAR-T cells through transcriptional and epigenetic armoring.Theranostics · 2025Review
- Article
- Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Zhi-Chun DingGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA. gzhou@augusta.edu zding@augusta.edu hshi@augusta.edu.ORCID 0000-0001-6322-8641
Huidong ShiGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA. gzhou@augusta.edu zding@augusta.edu hshi@augusta.edu.
Nada S AboelellaGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-9009-9897
Kateryna FesenkovaGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Eun-Jeong ParkGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Zhuoqi LiuGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-7293-0886
Lirong PeiGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Jiaqi LiCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0001-9357-8511
Richard A McIndoeCenter for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-3040-3631
Hongyan XuDivision of Biostatistics and Data Science, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0001-7432-9018
Gary A PiazzaUniversity of South Alabama Mitchell Cancer Institute, Mobile, AL, USA.ORCID 0000-0003-4418-887X
Bruce R BlazarDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9608-9841
David H MunnGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-7711-2858
Gang ZhouGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA. gzhou@augusta.edu zding@augusta.edu hshi@augusta.edu.ORCID 0000-0001-8967-114X
Augusta University · USNanchang University · CNUniversity of Minnesota · USUSA Mitchell Cancer Institute · US
Funding
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Mark J Osborn · 1995 to 2026
$48.2MReprogramming the TME for immunogenic antigen-presentationR01CA103320 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MUNN, DAVID H. · 2003 to 2024
$6.0MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MIn Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4MRole of IDO malignancyR01CA096651 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MUNN, DAVID H. · 2003 to 2016
$3.3MExploiting the immunomodulatory effects of sulindac and novel non-COX inhibitory derivatives for cancer treatmentR01CA238514 · NCI · AUGUSTA UNIVERSITY · PI PIAZZA, GARY A, ZHOU, GANG · 2020 to 2024
$2.1MChemotherapy-induced MDSCs and antitumor immunityR01CA215523 · NCI · AUGUSTA UNIVERSITY · PI ZHOU, GANG · 2017 to 2021
$1.7MPTEN, Tregs and MDSCs in the tumor microenvironmentR01CA211229 · NCI · AUGUSTA UNIVERSITY · PI MUNN, DAVID H. · 2017 to 2021
$1.7MIdentification of clonal DNA methylation and chromatin accessibilityR03CA212829 · NCI · AUGUSTA UNIVERSITY · PI CHOI, JEONG-HYEON, SHI, HUIDONG · 2017 to 2018
$152kNCI NIH HHS P01 CA065493NCI NIH HHS R01 CA096651NCI NIH HHS R01 CA103320NCI NIH HHS R01 CA211229NCI NIH HHS R01 CA215523NCI NIH HHS R01 CA238514NCI NIH HHS R03 CA212829NHLBI NIH HHS R01 HL056067NIAID NIH HHS R37 AI034495
Abstract
The presence of polyfunctional CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansImmunotherapy, AdoptiveLymphomaMaleMiceMice, TransgenicPrimary Cell CultureReceptors, Chimeric AntigenRNA-SeqReceptors, Chimeric AntigenStat5a protein, mouseSTAT5 Transcription Factor
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.