Evidence map›Paper›PMID 33127508›Full record

ReviewCurrent opinion in insect science2021

Steroid hormones, dietary nutrients, and temporal progression of neurogenesis.

Chhavi Sood, Susan E Doyle, Sarah E Siegrist

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in insect science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026
    Review
  2. The Hox Gene,Molecular biology of the cell · 2025
    Article
  3. The Hox Gene,bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chhavi SoodDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Susan E DoyleDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Sarah E SiegristDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA. Electronic address: ses4gr@virginia.edu.
University of Virginia · US

Funding

Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formationR35GM141886 · NIGMS · UNIVERSITY OF VIRGINIA · PI SIEGRIST, SARAH ELIZABETH · 2021 to 2025
$2.3M
Cell growth and proliferation control in neural stem cellsR01GM120421 · NIGMS · UNIVERSITY OF VIRGINIA · PI SIEGRIST, SARAH ELIZABETH · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM120421NIGMS NIH HHS R35 GM141886
6 · The paper itself

Abstract

Temporal patterning of neural progenitors, in which different factors are sequentially expressed, is an evolutionarily conserved strategy for generating neuronal diversity during development. In the Drosophila embryo, mechanisms that mediate temporal patterning of neural stem cells (neuroblasts) are largely cell-intrinsic. However, after embryogenesis, neuroblast temporal patterning relies on extrinsic cues as well, as freshly hatched larvae seek out nutrients and other key resources in varying natural environments. We recap current understanding of neuroblast-intrinsic temporal programs and discuss how neuroblast extrinsic cues integrate and coordinate with neuroblast intrinsic programs to control numbers and types of neurons produced. One key emerging extrinsic factor that impacts temporal patterning of neuroblasts and their daughters as well as termination of neurogenesis is the steroid hormone, ecdysone, a known regulator of large-scale developmental transitions in insects and arthropods. Lastly, we consider evolutionary conservation and discuss recent work on thyroid hormone signaling in early vertebrate brain development.

Indexed as

NeurogenesisAnimalsBiological EvolutionDietDrosophila melanogasterEcdysoneNeural Stem CellsSignal TransductionThyroid HormonesVertebratesEcdysoneThyroid Hormones

Identifiers

PMID33127508
PMCPMC8058227
OpenAlexW3096113120

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.