ArticleActa biomaterialia2021
Mechanical, structural, and physiologic differences in human elastic and muscular arteries of different ages: Comparison of the descending thoracic aorta to the superficial femoral artery.
Article in Acta biomaterialia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
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- Multimodal intra-subject characterization of abdominal aortic aneurysm pathophysiology: a case study.Biomechanics and modeling in mechanobiology · 2026Article
- Stent-graft compliance modulates regional mechanical and structural remodeling of the aorta.Acta biomaterialia · 2026Article
- Windkessel Preserving Aortic Stent Graft Attenuates Left Ventricular Remodelling after Thoracic Endovascular Aortic Repair in a Porcine Model.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2026Article
- Association of LDL protein cargo with segmental pulse wave velocity in older adults in the atherosclerosis risk in communities study.Frontiers in aging · 2026Article
- Chitosan Nanofibrous Dressing Increased Angiogenesis and Anti-inflammatory Response in an Acute Wound Model in Rats: A Comparative Study.Annals of biomedical engineering · 2025Article
- Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.European heart journal · 2025Review
- EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS.bioRxiv : the preprint server for biology · 2025Article
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Sex- and region-specific differences in microstructural remodeling and passive biomechanics of the aorta correlate with aneurysm propensity in a mouse model of severe Marfan syndrome.Acta biomaterialia · 2025Article
- Large animal model of controlled peripheral artery calcification.Acta biomaterialia · 2025Article
- Photoplethysmography-Derived Arterial Stiffness Index Delivered Greater Cardiovascular Prevention Value to Non-Elderly: A Retrospective Cohort Study Based on UK Biobank.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Variations in stiffness and structure of the human aorta along its length.Scientific reports · 2025Article
- Microstructural remodeling under single fiber tensional homeostasis recreates distinctive ex vivo mechanical behavior of arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Optimizing Arterial Tissue Thickness Measurement Protocols: Digital Vernier Caliper Versus Digital Thickness Gauge.Methods and protocols · 2024Article
- Effects of age, elastin density, and glycosaminoglycan accumulation on the delamination strength of human thoracic and abdominal aortas.Acta biomaterialia · 2024Article
- A viscoelastic constitutive framework for aging muscular and elastic arteries.Acta biomaterialia · 2024Article
- Experimental Protocols to Test Aortic Soft Tissues: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Mechanical, structural, and morphological differences in the iliac arteries.Journal of the mechanical behavior of biomedical materials · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Elastic and muscular arteries differ in structure, function, and mechanical properties, and may adapt differently to aging. We compared the descending thoracic aortas (TA) and the superficial femoral arteries (SFA) of 27 tissue donors (average 41±18 years, range 13-73 years) using planar biaxial testing, constitutive modeling, and bidirectional histology. Both TAs and SFAs increased in size with age, with the outer radius increasing more than the inner radius, but the TAs thickened 6-fold and widened 3-fold faster than the SFAs. The circumferential opening angle did not change in the TA, but increased 2.4-fold in the SFA. Young TAs were relatively isotropic, but the anisotropy increased with age due to longitudinal stiffening. SFAs were 51% more compliant longitudinally irrespective of age. Older TAs and SFAs were stiffer, but the SFA stiffened 5.6-fold faster circumferentially than the TA. Physiologic stresses decreased with age in both arteries, with greater changes occurring longitudinally. TAs had larger circumferential, but smaller longitudinal stresses than the SFAs, larger cardiac cycle stretch, 36% lower circumferential stiffness, and 8-fold more elastic energy available for pulsation. TAs contained elastin sheets separated by smooth muscle cells (SMCs), collagen, and glycosaminoglycans, while the SFAs had SMCs, collagen, and longitudinal elastic fibers. With age, densities of elastin and SMCs decreased, collagen remained constant due to medial thickening, and the glycosaminoglycans increased. Elastic and muscular arteries demonstrate different morphological, mechanical, physiologic, and structural characteristics and adapt differently to aging. While the aortas remodel to preserve the Windkessel function, the SFAs maintain higher longitudinal compliance.
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Registered trials
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