Evidence map›Paper›PMID 33127291›Full record

Trial reportNeuromuscular disorders : NMD2020

Respiratory muscle training in late-onset Pompe disease: Results of a sham-controlled clinical trial.

Harrison N Jones, Maragatha Kuchibhatla, Kelly D Crisp, Lisa D Hobson-Webb, Laura Case, Milisa T Batten, Jill A Marcus, Richard M Kravitz, Priya S Kishnani

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuromuscular disorders : NMD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05951790 (Efficacy and Feasibility of Inspiratory Muscle Training), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05951790 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy and Feasibility of Inspiratory Muscle Training (IMT) in Adult People With Pompe Disease: a Multicentre, Cross-over Randomized Control Trial (RCT)

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2024Enrolled20ConditionsGlycogen Storage Disease Type II, Pompe Disease (Late-onset)ArmsInspiratory Muscle Training (IMT), Inspiratory Muscle Training (IMT) + Air Stacking
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Respiratory muscle training in neuromuscular disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Inspiratory Muscle Training in Nemaline Myopathy.Journal of neuromuscular diseases · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Harrison N JonesDepartment of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, 155 Baker House, Trent Dr., DUMC 3887, Durham, NC 27710, USA; Division of Speech Pathology and Audiology, Duke University Medical Center, Durham, NC, USA. Electronic address: harrison.jones@duke.edu.
Maragatha KuchibhatlaDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
Kelly D CrispDepartment of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, 155 Baker House, Trent Dr., DUMC 3887, Durham, NC 27710, USA.
Lisa D Hobson-WebbDepartment of Neurology, Neuromuscular Division, Duke University School of Medicine, Durham, NC, USA.
Laura CaseDivision of Physical Therapy, Duke University School Of Medicine, Durham, NC, USA.
Milisa T BattenDivision of Speech Pathology and Audiology, Duke University Medical Center, Durham, NC, USA.
Jill A MarcusDivision of Speech Pathology and Audiology, Duke University Medical Center, Durham, NC, USA.
Richard M KravitzDivision of Pediatric Pulmonary and Sleep Medicine, Duke University School of Medicine, Durham, NC, USA.
Priya S KishnaniDepartment of Pediatrics, Division of Medical Genetics, Duke University School of Medicine, Durham, NC, USA.
Duke University · USDuke University Hospital · USDuke Medical Center · US

Funding

Respiratory Muscle Training in Late-Onset Pompe DiseaseR21AR069880 · NIAMS · DUKE UNIVERSITY · PI JONES, HARRISON N. · 2016 to 2018
$526k
NIAMS NIH HHS R21 AR069880
6 · The paper itself

Abstract

To address progressive respiratory muscle weakness in late-onset Pompe disease (LOPD), we developed a 12-week respiratory muscle training (RMT) program. In this exploratory, double-blind, randomized control trial, 22 adults with LOPD were randomized to RMT or sham-RMT. The primary outcome was maximum inspiratory pressure (MIP). Secondary and exploratory outcomes included maximum expiratory pressure (MEP), peak cough flow, diaphragm ultrasound, polysomnography, patient-reported outcomes, and measures of gross motor function. MIP increased 7.6 cmH

Indexed as

AdultAgedBreathing ExercisesDiaphragmDouble-Blind MethodFemaleGlycogen Storage Disease Type IIHumansInhalationMaleMiddle AgedMuscle WeaknessRespiratory Function TestsRespiratory MusclesUltrasonographyLate-onset Pompe diseaseMaximum expiratory pressureMaximum inspiratory pressurePompe diseaseRandomized control trialRespiratory muscle training

Identifiers

PMID33127291
PMCPMC7680435
OpenAlexW3090354606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.