Evidence map›Paper›PMID 33126731›Full record

ArticleGenes2020

Genomic Diversity in Sporadic Breast Cancer in a Latin American Population.

Lucía Brignoni, Mónica Cappetta, Valentina Colistro, Mónica Sans, Nora Artagaveytia, Carolina Bonilla, Bernardo Bertoni

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. FGFR2 genetic variants in women with breast cancer.Molecular medicine reports · 2023
    Article
  6. Molecular medicine reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Lucía BrignoniDepartamento de Genética, Facultad de Medicina, Universidad de la República, Paysandú 60000, Uruguay.ORCID 0000-0002-3085-9647
Mónica CappettaDepartamento de Genética, Facultad de Medicina, Universidad de la República, Paysandú 60000, Uruguay.ORCID 0000-0003-2015-0156
Valentina ColistroDepartamento de Métodos Cuantitativos, Facultad de Medicina, Universidad de la República, Paysandú 60000, Uruguay.ORCID 0000-0002-5727-4980
Mónica SansDepartamento de Antropología Biológica, Facultad de Humanidades y Ciencias, Universidad de la República, Paysandú 60000, Uruguay.
Nora ArtagaveytiaDepartamento Básico de Medicina, Facultad de Medicina, Universidad de la República, Paysandú 60000, Uruguay.ORCID 0000-0001-8798-7941
Carolina BonillaDepartamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo SP 01246-903, Brazil.ORCID 0000-0002-9972-6383
Bernardo BertoniDepartamento de Genética, Facultad de Medicina, Universidad de la República, Paysandú 60000, Uruguay.ORCID 0000-0002-9418-2911
Universidad de la República de Uruguay · UYUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among Latin American women, breast cancer incidences vary across populations. Uruguay and Argentina have the highest rates in South America, which are mainly attributed to strong, genetic European contributions. Most genetic variants associated with breast cancer were described in European populations. However, the vast majority of genetic contributors to breast cancer risk remain unknown. Here, we report the results of a candidate gene association study of sporadic breast cancer in 176 cases and 183 controls in the Uruguayan population. We analyzed 141 variants from 98 loci that have been associated with overall breast cancer risk in European populations. We found weak evidence for the association of risk variants rs294174 (

Indexed as

Breast NeoplasmsCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansLatin AmericaMiddle AgedPolymorphism, Single NucleotideRisk FactorsUruguaybreast cancerLatin Americapopulation genetics

Identifiers

PMID33126731
PMCPMC7716199
OpenAlexW3094883913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.