Evidence map›Paper›PMID 33126697›Full record

ArticleInternational journal of environmental research and public health2020

The Effect of Smoking during Pregnancy on Severity and Directionality of Externalizing and Internalizing Symptoms: A Genetically Informed Approach.

Mikael O Ekblad, Kristine Marceau, Emily Rolan, Rohan H C Palmer, Alexandre Todorov, Andrew C Heath, Valerie S Knopik

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Special Issue on the Effects of Prenatal Smoking/Nicotine Exposure on the Child's Health.International journal of environmental research and public health · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Mikael O EkbladDepartment of General Practice, Institute of Medicine, Turku University and Turku University Hospital, 20014 Turku, Finland.ORCID 0000-0001-8369-4359
Kristine MarceauDepartment of Human Development and Family Studies, Purdue University, West Lafayette, IN 47906, USA.ORCID 0000-0002-8924-6597
Emily RolanDepartment of Psychology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-9045-8757
Rohan H C PalmerDepartment of Psychology, Behavioral Genetics of Addiction Laboratory, Emory University, Atlanta, GA 30322, USA.
Alexandre TodorovDepartment of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Andrew C HeathDepartment of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Valerie S KnopikDepartment of Human Development and Family Studies, Purdue University, West Lafayette, IN 47906, USA.
Purdue University West Lafayette · USWashington University in St. Louis · USEmory University · USMichigan State University · USTurku University Hospital · FI

Funding

Bio-behavioral Developmental Origins of Adolescent Substance AbuseK01DA039288 · NIDA · PURDUE UNIVERSITY · PI MARCEAU, KRISTINE · 2016 to 2020
$876k
NIH HHS AA017688NIH HHS AA021492NIH HHS AA07728NIH HHS AA09022NIH HHS AA11998NIH HHS DA023134NIH HHS DA17671NIH HHS HD049024NIH HHS K01DA039288NIH HHS R01DA04272
6 · The paper itself

Abstract

The objective was to examine the association between maternal smoking during pregnancy (SDP) and (I) severity and (II) directionality of externalizing and internalizing symptoms in a sample of sibling pairs while rigorously controlling for familial confounds. The Missouri Mothers and Their Children Study is a family study (N = 173 families) with sibling pairs (aged 7 to 16 years) who are discordant for exposure to SDP. This sibling comparison study is designed to disentangle the effects of SDP from familial confounds. An SDP severity score was created for each child using a combination of SDP indicators (timing, duration, and amount). Principal component analysis of externalizing and internalizing behavior, assessed with the Child Behavior Checklist and Teacher Report Form, was used to create symptom severity and directionality scores. The variance in severity and directionality scores was primarily a function of differences between siblings (71% and 85%, respectively) rather than differences across families (29% and 15%, respectively). The severity score that combines externalizing and internalizing symptom severity was not associated with SDP. However, a significant within-family effect of SDP on symptom directionality (b = 0.07,

Indexed as

Prenatal Exposure Delayed EffectsSmokingAdolescentAntisocial Personality DisorderBehavioral SymptomsChildFemaleHumansMaleMissouriPregnancySiblingsgenetically-informed designshealth consequencesprenatal exposuresibling comparisontobacco

Identifiers

PMID33126697
PMCPMC7662383
OpenAlexW3097012419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.