ArticleBiomedicines2020
Depression as a Risk Factor for Dementia and Alzheimer's Disease.
Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Worldwide Occurrence of HIV-Associated Neurocognitive Disorders and Its Associated Factors: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Depression and hippocampal subfield volume in older adults.Translational psychiatry · 2026Article
- Long-term patterns of depressive symptoms and cognitive aging in middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2026Article
- Multiscale dispersion entropy of resting-state EEG in older adults with Alzheimer's disease, mild cognitive impairment, and remitted major depressive disorder.Journal of Alzheimer's disease : JAD · 2026Article
- Quality of life analysis in community pharmacy using deep learning and explainability methods.JAMIA open · 2026Article
- Review
- Article
- The Role of miRNAs in the Differential Diagnosis of Alzheimer's Disease and Major Depression: A Bioinformatics-Based Approach.International journal of molecular sciences · 2025Article
- Longitudinal associations of depression and diabetes with Alzheimer's disease and related dementias risk among American Indian and Alaska Native peoples.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults, a NHANES weighted analysis.Scientific reports · 2025Article
- Glucose Metabolic Abnormality: A Crosstalk between Depression and Alzheimer's Disease.Current neuropharmacology · 2025Review
- The diagnostic pathway of Alzheimer's disease in real-world clinical practice in Spain: results from the Adelphi Dementia Disease Specific Programme™.Frontiers in neurology · 2025Article
- Critical Review of Neurobiological Evidence for Relationships Between Social Isolation, Loneliness and the Risk of Developing of Alzheimer's Disease: A New Model.Journal of aging research · 2025Review
- Effects of group music sessions on cognitive and psychological functions in healthy older adults.Frontiers in aging · 2025Article
- A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024.Frontiers in neuroscience · 2025Article
- Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: a longitudinal study using amyloid-β PET images and neuropsychological measurements.Alzheimer's research & therapy · 2024Article
- The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Observational
- Gendered differences in the prevalence and associated factors of dementia in Ghana: a cross-sectional survey.BMC psychiatry · 2024Article
- The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals.Current issues in molecular biology · 2024Review
- Multifaceted Music Therapy for Depression in Dementia: A Network Meta-Analysis of Randomized Controlled Trials.European journal of investigation in health, psychology and education · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preventing the onset of dementia and Alzheimer's disease (AD), improving the diagnosis, and slowing the progression of these diseases remain a challenge. The aim of this study was to elucidate the association between depression and dementia/AD and to identify possible relationships between these diseases and different sociodemographic and clinical features. In this regard, a case-control study was conducted in Spain in 2018-2019. The definition of a case was: A person ≥ 65 years old with dementia and/or AD and a score of 5-7 on the Global Deterioration Scale (GDS). The sample consisted of 125 controls; among the cases, 96 had dementia and 74 had AD. The predictor variables were depression, dyslipidemia, type 2 diabetes mellitus, and hypertension. The results showed that depression, diabetes mellitus, and older age were associated with an increased likelihood of developing AD, with an Odds Ratio (OR) of 12.9 (95% confidence interval (CI): 4.3-39.9), 2.8 (95% CI: 1.1-7.1) and 1.15 (95% CI: 1.1-1.2), respectively. Those subjects with treated dyslipidemia were less likely to develop AD (OR 0.47, 95% CI: 0.22-1.1). Therefore, depression and diabetes mellitus increase the risk of dementia, whereas treated dyslipidemia has been shown to reduce this risk.
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