Evidence map›Paper›PMID 33126568›Full record

ArticleInternational journal of molecular sciences2020

The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression.

Cristabelle De Souza, Jill A Madden, Dennis Minn, Vigneshwari Easwar Kumar, Dennis J Montoya, Roshni Nambiar, Zheng Zhu, Wen-Wu Xiao, Neeki Tahmassebi, Harikumara Kathi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The Significance of CXCL1 in Cancer: An Overview of Molecular Mechanisms.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Cristabelle De SouzaDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Jill A MaddenThe Manton Center for Orphan Disease Research and The Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA.
Dennis MinnCollege of Information and Computer Sciences, University of Massachusetts, Amherst, MA 01003, USA.
Vigneshwari Easwar KumarDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Dennis J MontoyaDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Roshni NambiarDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Zheng ZhuDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.ORCID 0000-0002-4112-5294
Wen-Wu XiaoDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Neeki TahmassebiDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Harikumara KathiDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.ORCID 0000-0001-7242-8127
Nina NelsonDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Anthony N KarnezisDepartment of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA.
Jeremy ChienDepartment of Biochemistry and Molecular Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.ORCID 0000-0003-4744-8374
University of California Davis Medical Center · USCalifornia State University, Channel Islands · USBoston Children's Hospital · USUniversity of Massachusetts Amherst · USUniversity of New Mexico · US

Funding

U.S. Department of Defense W81XWH1010386
6 · The paper itself

Abstract

High-grade serous carcinoma (HGSC), the most lethal subtype of epithelial ovarian cancer (EOC), is characterized by widespread

Indexed as

Epithelial-Mesenchymal TransitionMutationPolymorphism, GeneticAnimalsApoptosisBiomarkers, TumorCell ProliferationChemokine CXCL1FemaleGene Expression Regulation, NeoplasticHumansMiceNeoplasm InvasivenessOvarian NeoplasmsPhenotypeTumor Cells, CulturedBiomarkers, TumorChemokine CXCL1CXCL1 protein, humanTP53 protein, humanTumor Suppressor Protein p53CXCL1mutant p53ovarian cancerP72R polymorphismtumor invasion

Identifiers

PMID33126568
PMCPMC7662892
OpenAlexW3095077494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.