Observational studyMedicine2020
Central nervous system aspergillosis in immunocompetent patients: Case series and literature review.
Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Two Cases of Isolated Intracranial Aspergilloma Mimicking Convexity and Skull Base Meningioma: Diagnostic and Radiological Dilemmas.Revista de neurologia · 2026Article
- Deep learning on meta-analytic data for therapeutic decision-making in central nervous system aspergillosis.BMC infectious diseases · 2026Article
- Case Report: Lung squamous cell carcinoma mimicking recurrent aspergillosis in systemic lupus erythematosus.Frontiers in medicine · 2026Article
- Silent Fungal Invasion: A Case of Aspergillus Brain Abscesses in an Immunocompetent Older Adult Patient.Cureus · 2025Article
- Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma.BMC infectious diseases · 2025Article
- Intracranial fungal mass imitating a high-grade glial lesion - is antifungal alone sufficient?Surgical neurology international · 2025Article
- A case of intracranial infection caused byMedical mycology case reports · 2024Article
- Aneurysm, meningitis, and subarachnoid hemorrhage secondary to intracranialQuantitative imaging in medicine and surgery · 2024Article
- Advances in differential diagnosis of cerebrovascular diseases in magnetic resonance imaging: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Infection due to Aspergillus flavus and Rhizopus oryzae complex in a patient with diabetes mellitusBiomedica : revista del Instituto Nacional de Salud · 2023Article
- A Complex Case of Aspergillus Infection of the Brain and Its Future Medical Implications.Cureus · 2022Article
- Rare case of aspergillus brain abscess in an immunocompromised patient.Clinical case reports · 2022Article
- Unusual manifestation of COVID-19-associated pulmonary aspergillosis: A case report.Clinical case reports · 2022Article
- A case of influenza-associated invasive aspergillosis with cerebral hemorrhage due to infectious vasculopathy.Radiology case reports · 2022Article
- Clinical-Pathological Conference Series from the Medical University of Graz : Case No 172: A 45-year-old truck driver with fever, vomiting, thrombocytopenia and renal failure.Wiener klinische Wochenschrift · 2021Article
- Rapid Genomic Diagnosis of Fungal Infections in the Age of Next-Generation Sequencing.Journal of fungi (Basel, Switzerland) · 2021Review
- Marine Bioactive Compounds againstAntibiotics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the clinical characteristics of central nervous system (CNS) aspergillosis in immunocompetent patients.This study enrolled six immunocompetent patients diagnosed with CNS aspergillosis. Additionally, we reviewed the clinical profiles for 28 cases reported in the literature. The age, gender, etiology of Aspergillus infection, clinical manifestations, location of the lesion, treatment, and prognosis were analyzed.There were 19 men (average age, 54.6 ± 14.3 years) and 15 women (average age, 47.0 ± 19.4 years). The clinical manifestations included headache (55.9%; n = 19), visual impairment (32.4%; n = 11), diplopia (32.4%; n = 11), hemiplegia (20.6%; n = 7), fever (17.6%; n = 6), and epilepsy (8.8%; n = 3). According to the radiological features, CNS aspergillosis lesions were divided into two subtypes: parenchymal lesions in the cerebral lobes (n = 11), and meningeal lesions in the meninges (n = 23). The patients with meningeal lesions are easy to be complicated with more serious cerebrovascular diseases, such as subarachnoid hemorrhage and massive infarction. Most of the lesions in brain parenchyma were abscess formation, and magnetic resonance imaging showed ring enhancement. The clinical diagnosis of Aspergillus infection was mainly based on brain biopsy (n = 14), autopsy (n = 8), pathological examination of adjacent brain tissues (n = 7), cerebrospinal fluid (CSF) or tissue culture (n = 3), and second-generation sequencing analysis of the CSF (n = 3). Clinical improvement was achieved in 23 cases, and 11 patients succumbed to the disease. Voriconazole treatment was effective in 24 (70.6%) cases.Immunocompetent subjects are also at risk for Aspergillus infections. Concomitant cerebrovascular diseases are common in patients with CNS aspergillosis, especially in patients with meningeal aspergillosis. Parenchymal aspergillosis lesions are usually localized and manifest as brain abscesses with annular enhancement on magnetic resonance imaging. Biopsy, CSF culture, and next-generation sequencing are mainstream diagnostic modalities. Voriconazole is an effective treatment for Aspergillus infection, and early diagnosis and treatment should be highlighted.
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