Evidence map›Paper›PMID 33126265›Full record

ArticleFolia microbiologica2021

Anti-phage serum antibody responses and the outcome of phage therapy.

M Łusiak-Szelachowska, R Międzybrodzki, W Fortuna, J Borysowski, Andrzej Górski

Open access · hybridAbstract read
In one paragraph

Article in Folia microbiologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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  17. [Bacteriophage Therapy: Retrospective Review and Future Prospects].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

M Łusiak-SzelachowskaBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
R MiędzybrodzkiBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
W FortunaBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland.
J BorysowskiDepartment of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
Andrzej GórskiBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), Wrocław, Poland. andrzej.gorski@hirszfeld.pl.ORCID http://orcid.org/0000-0002-0863-6041
Medical University of Warsaw · PLLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLWroclaw Medical University · PL

Funding

Polska Akademia Nauk Statutory funds
6 · The paper itself

Abstract

We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with high antibody production. In addition, there was no correlation between antibody level and the outcome of PT. These data, derived from a homogenous group of patients, confirm our earlier findings suggesting that the prognostic significance of serum anti-phage antibodies for the outcome of PT should be determined by relevant clinical trials.

Indexed as

Phage TherapyAntibodies, ViralBacteriophagesChronic DiseaseHumansNeutralization TestsRhinitisSinusitisTreatment OutcomeAntibodies, Viral

Identifiers

PMID33126265
PMCPMC7854414
OpenAlexW3097193280

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.