ArticleSocial science & medicine (1982)2020
Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy.
Article in Social science & medicine (1982), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Association between Adverse Childhood Experiences and Binge Drinking among Adults: The Moderating Effect of Race/Ethnicity.Journal of racial and ethnic health disparities · 2026Article
- Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- The influence of early childhood education and care on the relation between early-life social adversity and children's mental health in the environmental influences for Child Health Outcomes Program.Development and psychopathology · 2025Observational
- Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome.Placenta · 2025Article
- Programming the next generation of prenatal programming of stress research: A review and suggestions for the future of the field.Development and psychopathology · 2024Review
- Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood.Psychoneuroendocrinology · 2024Article
- The Impact of Maternal Interpersonal Violent Trauma and Related Psychopathology on Child Outcomes and Intergenerational Transmission.Current psychiatry reports · 2024Review
- Prenatal exposure to air pollution and BWGA Z-score: Modifying effects of placenta leukocyte telomere length and infant sex.Environmental research · 2024Article
- [Research progress on the mechanism of the impact of maternal childhood trauma on intergenerational transmission].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Recalibration of the stress response system over adult development: Is there a perinatal recalibration period?Development and psychopathology · 2023Review
- Long-Term Health Benefits of Occupational Licensing: Evidence from Midwifery Laws.Journal of health economics · 2023Article
- Intergenerational transmission of stress: Multi-domain stressors from maternal childhood and pregnancy predict children's mental health in a racially and socioeconomically diverse, multi-site cohort.Social psychiatry and psychiatric epidemiology · 2023Article
- Relationships between early-life family poverty and relative socioeconomic status with gestational diabetes, preeclampsia, and hypertensive disorders of pregnancy later in life.Annals of epidemiology · 2023Article
- Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review.Psychoneuroendocrinology · 2023Article
- A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children's Anxiety and Depression.Research on child and adolescent psychopathology · 2023Article
- Preterm Birth and Corticotrophin-Releasing Hormone as a Placental Clock.Endocrinology · 2022Review
- Young children's traumatic stress reactions to the COVID-19 pandemic: The long reach of mothers' adverse childhood experiences.Journal of affective disorders · 2022Article
- Cohort profile: the ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS).BMJ open · 2022Article
- Effect of individual or comorbid antenatal depression and anxiety on birth outcomes and moderation by maternal traumatic experiences and resilience.Journal of affective disorders reports · 2022Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
Abstract
Maternal psychosocial stress increases the risk of adverse birth and postnatal outcomes for the mother and child, but the role of maternal exposure to childhood traumatic events (CTE) and multi-domain psychosocial stressors for the level and rise of placental Corticotrophin-Releasing Hormone (pCRH) across pregnancy has been understudied. In a sociodemographically and racially diverse sample of 1303 women (64% Black, 36% White/others) with low-medical risk pregnancies at enrollment from Shelby County, Tennessee, USA, blood samples were drawn twice, corresponding roughly to second and third trimester, and extracted prior to conducting radioimmune assays for pCRH. Mothers reported CTE (physical abuse, sexual abuse, or family violence, in childhood), adulthood traumatic events, and interpersonal violence during pregnancy. Neighborhood crime/deprivation was derived using geospatially-linked objective databases. General linear and mixed models tested associations between stress exposure variables and pCRH levels and rate of rise, adjusting for obstetric/clinical/health related factors. Maternal CTE did not predict pCRH levels at time 1, but positively predicted levels at time 2, and the rate of rise in pCRH across pregnancy. Race did not moderate this association. No additional maternal stress exposures across adulthood or during pregnancy predicted pCRH outcomes. Findings indicate that childhood violence or abuse exposure can become biologically embedded in a manner predicting later prenatal physiology relevant for maternal and offspring health, and that such embedding may be specific to childhood, but not adulthood, stress. Findings also highlight the placental-fetal unit as a mechanistic pathway through which intergenerational transmission of the adverse effects of childhood adversities may occur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.