ArticleJournal of the American Chemical Society2020
Decarboxylative Alkyl Coupling Promoted by NADH and Blue Light.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- On-DNA photochemical methods for expanding DNA-encoded library (DEL) chemical space.RSC medicinal chemistry · 2026Review
- Red-Light Photoredox C-H Alkylation of Acceptor Heterocycles Enabled by Substoichiometric NADH.Organic letters · 2026Article
- Photoredox Unmasking of Aromatic C-H Bonds in Living Environments Enabled by Thianthrenium Salts.Journal of the American Chemical Society · 2026Article
- Biocompatible decarboxylative coupling enabled by N-hydroxynaphthalimide esters.Nature communications · 2025Article
- Photochemical synthesis of natural lipids in artificial and living cells.Nature communications · 2025Article
- Thermodynamic Cards of Classic NADH Models and Their Related Photoexcited States Releasing Hydrides in Nine Elementary Steps and Their Applications.Molecules (Basel, Switzerland) · 2025Article
- Facile enantioselective synthesis of multi-substituted norbornanes/norbornenes using a latent synthon strategy.Nature communications · 2024Article
- Mechanisms for radical reactions initiating fromBeilstein journal of organic chemistry · 2024Article
- On-DNA hydroalkylation ofChemical science · 2023Article
- Aryl versus Alkyl Redox-Active Diazoacetates ─ Light-Induced C-H Insertion or 1,2-Rearrangement.Organic letters · 2023Article
- Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(spChemical science · 2023Article
- Photochemical Methods Applied to DNA Encoded Library (DEL) Synthesis.Accounts of chemical research · 2023Article
- On-DNA Hydroalkylation to Introduce Diverse Bicyclo[1.1.1]pentanes and Abundant Alkyls via Halogen Atom Transfer.Journal of the American Chemical Society · 2022Article
- Metal-free deoxygenative coupling of alcohol-derived benzoates and pyridines for small molecules and DNA-encoded libraries synthesis.Chemical science · 2022Article
- Nickel-Mediated Synthesis of Non-AnomericThe Journal of organic chemistry · 2022Article
- Modular Enantioselective Synthesis ofACS catalysis · 2021Article
- Photoredox-mediated hydroalkylation and hydroarylation of functionalized olefins for DNA-encoded library synthesis.Chemical science · 2021Article
- Article
- Developments in Photoredox-Mediated Alkylation for DNA-Encoded Libraries.Trends in chemistry · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoexcited dihydronicotinamides like NADH and analogues have been found to generate alkyl radicals upon reductive decarboxylation of redox-active esters without auxiliary photocatalysts. This principle allowed aliphatic photocoupling between redox-active carboxylate derivatives and electron-poor olefins, displaying surprising water and air-tolerance and unusually high coupling rates in dilute conditions. The orthogonality of the reaction in the presence of other carboxylic acids and its utility in the functionalization of DNA is presented, notably using visible light in combination with NADH, the ubiquitous reductant of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.