Evidence map›Paper›PMID 33125764›Full record

ArticleAmerican journal of hematology2021

A phase 1b study of once-weekly carfilzomib combined with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma.

Melissa Alsina, Ola Landgren, Noopur Raje, Ruben Niesvizky, William I Bensinger, Jesus G Berdeja, Tibor Kovacsovics, David H Vesole, Belle Fang, Amy S Kimball and 1 more

Open access · hybridAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Melissa AlsinaMoffit Cancer Center, Tampa, Florida, USA.
Ola LandgrenMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Noopur RajeMassachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.
Ruben NiesvizkyWeill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA.
William I BensingerSwedish Cancer Institute, Seattle, Washington, USA.
Jesus G BerdejaSarah Cannon Research Institute, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-4362-0376
Tibor KovacsovicsHuntsman Cancer Institute at the University of Utah School of Medicine, Salt Lake City, Utah, USA.
David H VesoleJohn Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, USA.
Belle FangAmgen, Inc., Thousand Oaks, California, USA.
Amy S KimballAmgen, Inc., Thousand Oaks, California, USA.
David S SiegelJohn Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, USA.
Amgen (United States) · USHackensack University Medical Center · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USNewYork–Presbyterian Hospital · USSarah Cannon · USSwedish Medical Center · USUniversity of Utah · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Twice-weekly carfilzomib with lenalidomide-dexamethasone (Rd) is an effective regimen for newly diagnosed multiple myeloma (NDMM). Here we evaluated once-weekly carfilzomib with Rd (once-weekly KRd) in NDMM patients. The NDMM patients were enrolled regardless of transplant eligibility. Patients received carfilzomib on days 1, 8, and 15; lenalidomide 25 mg on days 1-21; and dexamethasone 40 mg on carfilzomib days (also day 22 for cycles 1-8) for ≤18, 28-day cycles. Enrollment initiated in a carfilzomib 20/70 mg/m

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsMultiple MyelomaDexamethasoneHumansLenalidomideOligopeptidescarfilzomibDexamethasoneLenalidomideOligopeptides

Identifiers

PMID33125764
PMCPMC7898514
OpenAlexW3094735140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.