Evidence map›Paper›PMID 33125710›Full record

ArticleEuropean journal of immunology2021

IFITM3-specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans.

Dannielle Wellington, Zixi Yin, Adi Abdel-Haq, Liwei Zhang, Jessica Forbester, Kerry Kite, Ushani Rajapaksa, Henry Laurenson-Schafer, Shokouh Makvandi-Nejad, Boquan Jin and 6 more

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Mechanisms of Differential Signal Transduction by IFNLR1 Variants.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Dannielle WellingtonMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.ORCID 0000-0002-9277-0306
Zixi YinMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Adi Abdel-HaqMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Liwei ZhangMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Jessica ForbesterMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Kerry KiteMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Ushani RajapaksaMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Henry Laurenson-SchaferMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Shokouh Makvandi-NejadMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Boquan JinFourth Military Medical University, Xian, China.
Emma BowesOxford Radcliffe Biobank, Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
Krishnageetha ManoharanOxford Radcliffe Biobank, Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
David Maldonado-PerezOxford Radcliffe Biobank, Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
Clare VerrillOxford Radcliffe Biobank, Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
Ian R HumphreysDivision of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University, Cardiff, UK.
Tao DongMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
University of Oxford · GBJohn Radcliffe Hospital · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNAir Force Medical University · CNInstitute of Infection and Immunity · CA

Funding

Medical Research Council G1000800Medical Research Council MR/L018942/1Wellcome Trust 207503/Z/17/Z
6 · The paper itself

Abstract

Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells.

Indexed as

A549 CellsAntiviral AgentsCD4-Positive T-LymphocytesCell LineCell Line, TumorHEK293 CellsHumansInterferon Type ILymphocytesMembrane ProteinsRNA-Binding ProteinsAntiviral AgentsIFITM3 protein, humanInterferon Type IMembrane ProteinsRNA-Binding ProteinsIFITM3IFNinnate immunitymyeloid cellsviral restriction

Identifiers

PMID33125710
PMCPMC7983929
OpenAlexW3093666624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.