ArticleEuropean journal of nutrition2021
Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring the Role of Food and Food-Related Compounds in Parkinson's Disease.Foods (Basel, Switzerland) · 2026Review
- Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis.Nutrition journal · 2025Article
- Bioactive and neoformed compounds in coffee: Dietary intake and population exposure in Neiva, Colombia.Food chemistry: X · 2025Article
- From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects.Nutrition reviews · 2025Review
- Can the Total Body Water and Total Fat Mass Predict Kidney Stone Recurrence in Overweight and Obese Patients?Cureus · 2024Article
- An umbrella review of meta-analysis to understand the effect of coffee consumption and the relationship between stroke, cardiovascular heart disease, and dementia among its global users.Journal of family medicine and primary care · 2024Review
- Does dietary intake of caffeine have an effect on transient global amnesia?Neuropsychopharmacology reports · 2024Article
- The Relationship between Beverages Consumption and Cognitive Impairment in Middle-Aged and Elderly Chinese Population.Nutrients · 2023Article
- Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study.BMC medicine · 2023Article
- Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function?Frontiers in nutrition · 2023Article
- Diet in the Prevention of Alzheimer's Disease: Current Knowledge and Future Research Requirements.Nutrients · 2022Review
- Article
- Caffeine Intake and Its Sex-Specific Association with General Anxiety: A Cross-Sectional Analysis among General Population Adults.Nutrients · 2022Article
- Caffeine intake improves the cognitive performance of patients with chronic kidney disease.Frontiers in medicine · 2022Article
- The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats.Frontiers in microbiology · 2022Article
- Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia.Nutrients · 2021Review
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Authors and funding
54 authors at 20 institutions in 1 country.
Funding
Abstract
purposeCoffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS).
methodsPREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n = 6427; mean age = 65 ± 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment.
resultsTotal coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A).
conclusionsCoffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS.
trial registrationISRCTN89898870. Registration date: July 24, 2014.
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