Evidence map›Paper›PMID 33125559›Full record

ArticleEuropean radiology2021

Computed tomography semi-automated lung volume quantification in SARS-CoV-2-related pneumonia.

Davide Ippolito, Maria Ragusi, Davide Gandola, Cesare Maino, Anna Pecorelli, Simone Terrani, Marta Peroni, Teresa Giandola, Marco Porta, Cammillo Talei Franzesi and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Artificial intelligence algorithms based approach in evaluating COVID-19 patients and management.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025
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  18. Pulmonary function and COVID-19.Current opinion in physiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Davide IppolitoDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy. davide.atena@tiscalinet.it.ORCID http://orcid.org/0000-0002-2696-7047
Maria RagusiDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Davide GandolaDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Cesare MainoDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Anna PecorelliDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Simone TerraniPhilips Healthcare, Viale Sacra 235, Milan, MI, 20126, Italy.
Marta PeroniPhilips Healthcare, Viale Sacra 235, Milan, MI, 20126, Italy.
Teresa GiandolaDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Marco PortaDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Cammillo Talei FranzesiDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
Sandro SironiDepartment of Diagnostic Radiology, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza, MB, 20900, Italy.
University of Milano-Bicocca · ITPhilips (Italy) · ITOspedale Papa Giovanni XXIII · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate a semi-automated segmentation and ventilated lung quantification on chest computed tomography (CT) to assess lung involvement in patients affected by SARS-CoV-2. Results were compared with clinical and functional parameters and outcomes.

methodsAll images underwent quantitative analyses with a dedicated workstation using a semi-automatic lung segmentation software to compute ventilated lung volume (VLV), Ground-glass opacity (GGO) volume (GGO-V), and consolidation volume (CONS-V) as absolute volume and as a percentage of total lung volume (TLV). The ratio between CONS-V, GGO-V, and VLV (CONS-V/VLV and GGO-V/VLV, respectively), TLV (CONS-V/TLV, GGO-V/TLV, and GGO-V + CONS-V/TLV respectively), and the ratio between VLV and TLV (VLV/TLV) were calculated.

resultsA total of 108 patients were enrolled. GGO-V/TLV significantly correlated with WBC (r = 0.369), neutrophils (r = 0.446), platelets (r = 0.182), CRP (r = 0.190), PaCO

conclusionThe use of quantitative semi-automated algorithm for lung CT elaboration effectively correlates the severity of SARS-CoV-2-related pneumonia with laboratory parameters and the need for invasive ventilation. KEY POINTS: • Pathological lung volumes, expressed both as GGO-V and as CONS-V, can be considered a useful tool in SARS-CoV-2-related pneumonia. • All lung volumes, expressed themselves and as ratio with TLV and VLV, correlate with laboratory data, in particular C-reactive protein and white blood cell count. • All lung volumes correlate with patient's outcome, in particular concerning invasive ventilation.

Indexed as

COVID-19PneumoniaHumansLungLung Volume MeasurementsRetrospective StudiesSARS-CoV-2Tomography, X-Ray ComputedArtificial intelligenceComputed tomography, X-rayInfection, coronavirusLung volume measurementsPneumonia

Identifiers

PMID33125559
PMCPMC7596627
OpenAlexW3095880346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.