ArticleEuropean radiology2021
Three-dimension amide proton transfer MRI of rectal adenocarcinoma: correlation with pathologic prognostic factors and comparison with diffusion kurtosis imaging.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferation status in rectal cancer: comparison with diffusion kurtosis imaging.Insights into imaging · 2026Article
- Amide proton transfer-weighted magnetic resonance imaging for predicting histopathology and biomarkers in rectal adenocarcinoma.Quantitative imaging in medicine and surgery · 2026Article
- Preoperative prediction of tumor budding grade in rectal cancer by combining APT histogram analysis and ADC MRI.European radiology experimental · 2026Article
- Evaluation of renal masses with CEST MRI: Protocol optimization and preliminary results.Magnetic resonance in medicine · 2025Article
- Enhancing the role of MRI in rectal cancer: advances from staging to prognosis prediction.European radiology · 2025Review
- Combination of PI-RADS version 2.1 and amide proton transfer values for the detection of clinically significant prostate cancer.BMC cancer · 2025Article
- Volumetric histogram analysis of amide proton transfer-weighted imaging for predicting complete tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal adenocarcinoma.European radiology · 2025Article
- Feasibility of Three-Dimension Chemical Exchange Saturation Transfer MRI for Predicting Tumor and Node Staging in Rectal Adenocarcinoma: An Exploration of Optimal ROI Measurement.Journal of imaging informatics in medicine · 2025Article
- Amide proton transfer-weighted MRI for assessing rectal adenocarcinoma T-staging and perineural invasion: a prospective study.European radiology · 2025Article
- Amide proton transfer-weighted imaging and T1 mapping as diagnostic tools to evaluate high-risk histopathologic phenotypes before surgery in rectal adenocarcinoma and their correlation with Ki-67 expression:a two-center study.Frontiers in oncology · 2025Article
- Application of cellular microstructural diffusion MRI (cell size imaging) in rectal lesions: a preliminary study.Frontiers in oncology · 2025Article
- Evaluation of functional magnetic resonance APT and DKI imaging for breast cancer.Cancer cell international · 2024Article
- Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging.Insights into imaging · 2024Article
- Prediction of Kirsten rat sarcoma (Quantitative imaging in medicine and surgery · 2024Article
- Using amide proton transfer-weighted magnetic resonance imaging (MRI) in peritumor tissue to predict parametrial infiltration of cervical cancer: a case-control study.Quantitative imaging in medicine and surgery · 2024Article
- Added-value of 3D amide proton transfer MRI in assessing prognostic factors of cervical cancer: a comparative study with multiple model diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2023Article
- Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Whole-tumor amide proton transfer-weighted imaging histogram analysis to predict pathological extramural venous invasion in rectal adenocarcinoma: a preliminary study.European radiology · 2023Article
- Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer.Bioengineering (Basel, Switzerland) · 2023Article
- CEST-MRI for body oncologic imaging: are we there yet?NMR in biomedicine · 2023Review
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8 authors.
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Abstract
objectivesTo investigate the utility of 3D amide proton transfer (APT) MRI in predicting pathologic factors for rectal adenocarcinoma, in comparison with diffusion kurtosis imaging.
methodsSixty-one patients with rectal adenocarcinoma were enrolled in this prospective study. 3D APT and diffusion kurtosis imaging (DKI) were performed. Mean APT-weighted signal intensity (APTw SI), mean kurtosis (MK), mean diffusivity (MD), and ADC values of tumors were calculated on these maps. Pathological analysis included WHO grades, pT stages, pN stages, and extramural venous invasion (EMVI) status. Student's t test, Spearman correlation, and receiver operating characteristics (ROC) analysis were used for statistical analysis.
resultsHigh-grade rectal adenocarcinoma showed significantly higher mean APTw SI and MK values (2.771 ± 0.384 vs 2.108 ± 0.409, 1.167 ± 0.216 vs 1.045 ± 0.175, respectively; p < 0.05). T3 rectal adenocarcinoma demonstrated higher mean APTw SI and MK than T2 tumors (2.433 ± 0.467 vs 1.900 ± 0.302, p < 0.05). No kurtosis, diffusivity, and ADC differences were found between T2 and T3 tumors. Tumors with lymph node metastasis and EMVI involvement showed significantly higher mean APTw SI, MK. No difference was found in diffusivity and ADC between pN0 and pN1-2 groups, and EMVI-negative and EMVI-positive statuses. Mean APTw SI exhibited a significantly high positive correlation with WHO grades, demonstrating 92.31% sensitivity and 79.17% specificity for distinguishing low- from high-grade rectal adenocarcinoma, providing a better diagnostic capacity than MK, MD, and mean ADC values.
conclusion3D-APT could serve as a non-invasive biomarker for evaluating prognostic factors of rectal adenocarcinoma. KEY POINTS: • Mean APTw SI was significantly higher in high-grade compared to low-grade rectal adenocarcinoma. • Mean APTw SI was significantly higher in T3 stage rectal adenocarcinoma, with lymph node metastasis, or in EMVI-positive status. • APTw SI exhibited greater diagnostic capability in discriminating low-grade from high-grade rectal adenocarcinoma, compared with kurtosis, diffusivity, and ADC.
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