Evidence map›Paper›PMID 33125519›Full record

SynthesisEuropean journal of pediatrics2021

Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis.

Risa Hashimoto, Maiko Suto, Mariko Tsuji, Hatoko Sasaki, Kenji Takehara, Akira Ishiguro, Masaya Kubota

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Risa HashimotoCenter for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. hashimoto-r@ncchd.go.jp.ORCID http://orcid.org/0000-0002-9070-5041
Maiko SutoDepartment of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
Mariko TsujiDepartment of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
Hatoko SasakiMedical Support Center for Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.
Kenji TakeharaDepartment of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
Akira IshiguroCenter for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Masaya KubotaDivision of Neurology, National Center for Child Health and Development, Tokyo, Japan.
National Center For Child Health and Development · JP

Funding

a Grant-in-Aid for the National Center for Child Health and Development No award number
6 · The paper itself

Abstract

The efficacy of antipyretics for preventing febrile seizure recurrence has been reported by a recent study, and the results might overturn previous evidence. We systematically reviewed the efficacy of antipyretics in the prevention of febrile seizure recurrence in children focused on the timing of its administration. We searched the Medline, Embase, and Cochrane Central Register of Controlled Trials databases for randomized and quasi-randomized trials and prospective non-randomized studies of aged up to 60 months, diagnosed with febrile seizure, who were treated with antipyretics. Data were extracted from eight studies. Only one study reported that antipyretics prevented the recurrence of febrile seizures within the same fever episode (9.1% in the acetaminophen group vs. 23.5% in the control group, p < 0.01). Four studies found no evidence for the efficacy of antipyretics in preventing febrile seizure recurrence in distant fever episodes (odds ratio, 0.92; 95% confidence interval, 0.57-1.48, for two randomized controlled studies).Conclusion: This review provides very limited support for the use of antipyretics in preventing febrile seizure recurrence within the same fever episode and no evidence for its use in distant fever episodes. New studies are required to evaluate this topic further and determine whether the effectiveness of antipyretics is based on intervention timing. What is Known: • Reviews of prophylactic drug management among febrile seizure children found that antipyretics had no significant benefits. • Recent data suggest that antipyretics are effective in preventing febrile seizures. What is New: • Weak evidence suggests a possible role in preventing febrile seizure recurrence within the same fever episode. • There is clearly no role for antipyretic prophylaxis in preventing febrile seizures during distant fever episodes.

Indexed as

AntipyreticsPharmaceutical PreparationsSeizures, FebrileAcetaminophenAgedChildHumansProspective StudiesRecurrenceAcetaminophenAntipyreticsPharmaceutical PreparationsAntipyreticsAntiseizure drugsFebrile seizurePreventionRecurrenceSystematic review

Identifiers

PMID33125519
OpenAlexW3094761796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.