Evidence map›Paper›PMID 33125518›Full record

Trial reportClinical oral investigations2021

Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial.

Cindy Grace Pérez-Pacheco, Natalie Ap Rodrigues Fernandes, Fernando Lucas Primo, Antonio Claudio Tedesco, Emily Bellile, Belen Retamal-Valdes, Magda Feres, Morgana Rodrigues Guimarães-Stabili, Carlos Rossa

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  8. SmartGel OV: A NaturalMedicina (Kaunas, Lithuania) · 2025
    Observational
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  16. Treatment of periodontal disease: does drug delivery matter?Frontiers in bioengineering and biotechnology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Cindy Grace Pérez-PachecoDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil.
Natalie Ap Rodrigues FernandesDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil.
Fernando Lucas PrimoDepartment of Bioprocess and Biotechnology, Faculty of Pharmaceutical Sciences of Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil.
Antonio Claudio TedescoDepartment of Chemistry, Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Emily BellileBiostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Belen Retamal-ValdesDepartment of Periodontology and Oral Implantology, Dental Research Division, Universidade de Guarulhos - UNG, Sao Paulo, SP, Brazil.
Magda FeresDepartment of Periodontology and Oral Implantology, Dental Research Division, Universidade de Guarulhos - UNG, Sao Paulo, SP, Brazil.
Morgana Rodrigues Guimarães-StabiliDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil.
Carlos RossaDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil. c.rossa@unesp.br.ORCID http://orcid.org/0000-0003-1705-5481
Centro Universitário de Araraquara · BRGuarulhos University · BRUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversity of Michigan · US

Funding

Conselho Nacional de Pesquisa (BR) CNPq 440588/2014-6
6 · The paper itself

Abstract

objectiveAssess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). MATERIALS AND

methodsTwenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N-Curc) or SRP+empty nanoparticles. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were monitored at baseline, 30, 90, and 180 days. IL-1α, IL-6, TNFα, and IL-10 in the gingival crevicular fluid (GCF) were assessed by ELISA, and counts of 40 bacterial species were determined by DNA hybridization at baseline, 3, 7, and 15 days post-therapy.

resultsPPD, CAL, and BOP were similarly and significantly improved in both experimental groups. There was no difference in GCF cytokine levels between experimental groups, although IL-6 was decreased at 3 days only in the N-Curc group. NPT reduced counts of red complex bacterial species in both groups. Veillonella Parvula counts increased significantly only in N-Curc group at 7 days, whereas Aggregatibacter actinomycetemcomitans counts increased significantly only in the control group from day 3 to day 15.

conclusionWe conclude that a single local administration of nanoencapsulated curcumin in periodontally diseased sites had no additive benefits to NPT. CLINICAL RELEVANCE: Our results showed that a single local application of curcumin-loaded nanoparticles associated with nonsurgical periodontal therapy did not improve clinical outcomes. Hence, our findings do not support the use of curcumin as an adjunct to nonsurgical periodontal therapy.

Indexed as

Chronic PeriodontitisCurcuminNanoparticlesPeriodontitisDental ScalingFollow-Up StudiesGingival Crevicular FluidHumansRoot PlaningVeillonellaCurcuminCurcuminDental ScalingNanoparticlesPeriodontitis

Identifiers

PMID33125518
OpenAlexW3097234896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.