ArticlePloS one2020
Thaumatin-like proteins and a cysteine protease inhibitor secreted by the pine wood nematode Bursaphelenchus xylophilus induce cell death in Nicotiana benthamiana.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Genome-Wide Identification and Characterization of Thaumatin-Like Proteins in Potato (Solanum tuberosum L.) and Their Role in Stress Tolerance.Molecular biotechnology · 2026Article
- Characterization of RcgA and RcgR, two rhizobial proteins involved in the modulation of plasmid transfer.Microbiology spectrum · 2026Article
- A review on the structure and function of plant thaumatin-like proteins.Frontiers in plant science · 2026Review
- Proteomic analysis of rice mutantFrontiers in plant science · 2025Article
- Pine wilt disease: what do we know from proteomics?BMC plant biology · 2024Review
- Dual functionality of pathogenesis-related proteins: defensive role in plants versus immunosuppressive role in pathogens.Frontiers in plant science · 2024Article
- Transcriptomic response of Pinus massoniana to infection stress from the pine wood nematode Bursaphelenchus xylophilus.Stress biology · 2023Article
- Article
- Genome-wide analysis of the Thaumatin-like gene family in Qingke (Frontiers in plant science · 2022Article
- Genes Encoding Potential Molecular Mimicry Proteins as the Specific Targets for DetectingFrontiers in plant science · 2022Article
- Novel Functional Analysis for Pathogenic Proteins ofFrontiers in plant science · 2022Article
- Reactive oxygen species and nitric oxide as mediators in plant hypersensitive response and stomatal closure.Plant signaling & behavior · 2021Article
- Comparative Secretome and Functional Analyses Reveal Glycoside Hydrolase Family 30 and Cysteine Peptidase as Virulence Determinants in the Pinewood NematodeFrontiers in plant science · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pine wilt disease (PWD) is an infectious disease of pines that typically kills affected trees. The causal pathogen of PWD is the pine wood nematode (PWN), Bursaphelenchus xylophilus. Understanding of the disease has advanced in recent years through the use of a highly sensitive proteomics procedure and whole genome sequence analysis; in combination, these approaches have enabled identification of proteins secreted by PWNs. However, the roles of these proteins during the onset of parasitism have not yet been elucidated. In this study, we used a leaf-disk assay based on transient overexpression in Nicotiana benthamiana to allow functional screening of 10 candidate pathogenic proteins secreted by PWNs. These proteins were selected based on previous secretome and RNA-seq analyses. We found that five molecules induced significant cell death in tobacco plants relative to a GFP-only control. Three of these proteins (Bx-TH1, Bx-TH2, and Bx-CPI) may have a role in molecular mimicry and likely make important contributions to inducing hypersensitive responses in host plants.
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