Evidence map›Paper›PMID 33125432›Full record

ArticlePloS one2020

Kingella negevensis shares multiple putative virulence factors with Kingella kingae.

Eric A Porsch, Pablo Yagupsky, Joseph W St Geme

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Microorganisms · 2022
    Review
  7. Pathogenic determinants ofFrontiers in pediatrics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Eric A PorschDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Pablo YagupskyClinical Microbiology Laboratory, Soroka University Medical Center, Beer-Sheva, Israel.
Joseph W St GemeDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0002-6787-9510
Children's Hospital of Philadelphia · USSoroka Medical Center · IL

Funding

Virulence mechanisms in the emerging pathogen Kingella kingaeR01AI121015 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI ST. GEME, JOSEPH W. · 2016 to 2020
$2.1M
NIAID NIH HHS R01 AI121015
6 · The paper itself

Abstract

Kingella negevensis is a newly described gram-negative bacterium in the Neisseriaceae family and is closely related to Kingella kingae, an important cause of pediatric osteoarticular infections and other invasive diseases. Like K. kingae, K. negevensis can be isolated from the oropharynx of young children, although at a much lower rate. Due to the potential for misidentification as K. kingae, the burden of disease due to K. negevensis is currently unknown. Similarly, there is little known about virulence factors present in K. negevensis and how they compare to virulence factors in K. kingae. Using a variety of approaches, we show that K. negevensis produces many of the same putative virulence factors that are present in K. kingae, including a polysaccharide capsule, a secreted exopolysaccharide, a Knh-like trimeric autotransporter, and type IV pili, suggesting that K. negevensis may have significant pathogenic potential.

Indexed as

Bacterial ProteinsFimbriae, BacterialHumansKingellaKingella kingaeNeisseriaceae InfectionsPolysaccharides, BacterialVirulenceVirulence FactorsBacterial ProteinsPolysaccharides, BacterialVirulence Factors

Identifiers

PMID33125432
PMCPMC7598479
OpenAlexW3095911907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.