ArticlePloS one2020
Class 1 integron-borne cassettes harboring blaCARB-2 gene in multidrug-resistant and virulent Salmonella Typhimurium ST19 strains recovered from clinical human stool samples, United States.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Presence of integrons and their correlation with multidrug resistance in Salmonella enterica serovar Typhimurium: Exploratory systematic reviewBiomedica : revista del Instituto Nacional de Salud · 2024Pooled it
- Whole-genome characterisation of high-risk ST131 and the emerging ST1193 UPEC lineages in Romanian patients with recurrent urinary tract infections.Frontiers in microbiology · 2026Article
- Genes and physiological strategies in bacterial antibiotic resistance.Frontiers in microbiology · 2026Review
- Mapping Integron-Associated AMR Genes in Whole Genome Sequences ofAntibiotics (Basel, Switzerland) · 2025Article
- Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods.Communications medicine · 2025Article
- Genomic dissection of the antimicrobial resistance epidemiology ofFrontiers in microbiology · 2025Article
- Comprehensive epidemiological profiling of poultry-derivedFrontiers in microbiology · 2025Article
- Antibiotic Resistance Profile ofMicroorganisms · 2024Article
- Optimizing the Antimicrobial Activity of Sodium Hypochlorite (NaClO) over Exposure Time for the Control ofAntibiotics (Basel, Switzerland) · 2024Article
- An Overview of Antimicrobial Resistance Profiles of Publicly AvailableFoodborne pathogens and disease · 2023Article
- Comparative Genomic Analysis Discloses Differential Distribution of Antibiotic Resistance Determinants between Worldwide Strains of the Emergent ST213 Genotype ofAntibiotics (Basel, Switzerland) · 2022Article
- Genomic insights ofFrontiers in microbiology · 2022Article
- Epidemiology ofFrontiers in microbiology · 2022Article
- Genomic Characterization ofFrontiers in microbiology · 2022Article
- Genomic diversity of antimicrobial resistance in non-typhoidalMicrobial genomics · 2021Article
- In Silico Detection of Antimicrobial Resistance Integrons inAntibiotics (Basel, Switzerland) · 2021Article
- Genomic Investigation ofFrontiers in microbiology · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
International lineages, such as Salmonella Typhimurium sequence type (ST) 19, are most often associated with foodborne diseases and deaths in humans. In this study, we compared the whole-genome sequences of five S. Typhimurium strains belonging to ST19 recovered from clinical human stool samples in North Carolina, United States. Overall, S. Typhimurium strains displayed multidrug-resistant profile, being resistance to critically and highly important antimicrobials including ampicillin, ticarcillin/clavulanic acid, streptomycin and sulfisoxazole, chloramphenicol, tetracycline, respectively. Interestingly, all S. Typhimurium strains carried class 1 integron (intl1) and we were able to describe two genomic regions surrounding blaCARB-2 gene, size 4,062 bp and 4,422 bp for S. Typhimurium strains (HS5344, HS5437, and HS5478) and (HS5302 and HS5368), respectively. Genomic analysis for antimicrobial resistome confirmed the presence of clinically important genes, including blaCARB-2, aac(6')-Iaa, aadA2b, sul1, tetG, floR, and biocide resistance genes (qacEΔ1). S. Typhimurium strains harbored IncFIB plasmid containing spvRABCD operon, as well as rck and pef virulence genes, which constitute an important apparatus for spreading the virulence plasmid. In addition, we identified several virulence genes, chromosomally located, while the phylogenetic analysis revealed clonal relatedness among these strains with S. enterica isolated from human and non-human sources obtained in European and Asian countries. Our results provide new insights into this unusual class 1 integron in virulent S. Typhimurium strains that harbors a pool of genes acting as potential hotspots for horizontal gene transfer providing readily adaptation to new surrounds, as well as being crucially required for virulence in vivo. Therefore, continuous genomic surveillance is an important tool for safeguarding human health.
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