Evidence map›Paper›PMID 33124765›Full record

ArticlePharmacology research & perspectives2020

Allosteric modulation of adenosine A1 and cannabinoid 1 receptor signaling by G-peptides.

Anja M Touma, Rabia U Malik, Tejas Gupte, Sivaraj Sivaramakrishnan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anja M ToumaDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-9953-9695
Rabia U MalikDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.
Tejas GupteDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.
Sivaraj SivaramakrishnanDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9541-6994
University of Minnesota · US

Funding

Emergent cellular functions of GPCRs and myosinsR35GM126940 · NIGMS · UNIVERSITY OF MINNESOTA · PI Sivaraj Sivaramakrishnan · 2018 to 2026
$3.8M
Elucidating Molecular Mechanisms of Hypertrophic Cardiomyopathy using Nano-Engineered Synthetic Myosin Thick FilamentsF30HL146089 · NHLBI · UNIVERSITY OF MINNESOTA · PI TOUMA, ANJA · 2019 to 2022
$152k
NHLBI NIH HHS 5F30HL146089-02NHLBI NIH HHS F30 HL146089NIGMS NIH HHS 1R35GM126940-01NIGMS NIH HHS R35 GM126940
6 · The paper itself

Abstract

While allosteric modulation of GPCR signaling has gained prominence to address the need for receptor specificity, efforts have mainly focused on allosteric sites adjacent to the orthosteric ligand-binding pocket and lipophilic molecules that target transmembrane helices. In this study, we examined the allosteric influence of native peptides derived from the C-terminus of the Gα subunit (G-peptides) on signaling from two Gi-coupled receptors, adenosine A1 receptor (A

Indexed as

Allosteric RegulationChromograninsDose-Response Relationship, DrugGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsPeptide FragmentsReceptor, Adenosine A1Receptor, Cannabinoid, CB1ChromograninsGINIP protein, ratGnas protein, mouseGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsIntracellular Signaling Peptides and ProteinsPeptide FragmentsReceptor, Adenosine A1Receptor, Cannabinoid, CB1adenosine-5’-(N-ethylcarboxamide)adenosine A1cannabinoidCB1GTP-binding proteinsN(6)-cyclopentyladenosinereceptorSCH 442 416signal transduction

Identifiers

PMID33124765
PMCPMC7596666
OpenAlexW3097845533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.