ArticleJournal of cardiovascular electrophysiology2020
Patient-reported outcomes and subsequent management in atrial fibrillation clinical practice: Results from the Utah mEVAL AF program.
Article in Journal of cardiovascular electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Perioperative atrial fibrillation after non-cardiac surgery - A narrative review.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Review
- Multidisciplinary Atrial Fibrillation Clinics: A Model for Comprehensive Management.Reviews in cardiovascular medicine · 2025Review
- Performance of off-the-shelf machine learning architectures and biases in low left ventricular ejection fraction detection.Heart rhythm O2 · 2024Article
- Comprehensive analysis of same day discharge after atrial fibrillation ablation: Clinical, cost, and patient reported outcomes.Journal of cardiovascular electrophysiology · 2024Article
- Atrial fibrillation and long-term cardiovascular outcomes: bringing the whole picture into focus.European heart journal · 2024Article
- Evaluation of disease burden and symptom scores in patients with acute atrial fibrillation in the emergency department.World journal of emergency medicine · 2024Article
- Major drivers of healthcare system costs and cost variability for routine atrial fibrillation ablation.Heart rhythm O2 · 2023Article
- Impact of Catheter Ablation on Stroke, Cognitive Decline and Dementia.Arrhythmia & electrophysiology review · 2021Review
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Authors and funding
15 authors.
Funding
Abstract
backgroundAtrial fibrillation (AF) significantly reduces health-related quality of life (HRQoL), previously measured in clinical trials using patient-reported outcomes (PROs). We examined AF PROs in clinical practice and their association with subsequent clinical management.
methodsThe Utah My Evaluation (mEVAL) program collects the Toronto AF Symptom Severity Scale (AFSS) in AF outpatients at the University of Utah. Baseline factors associated with worse AF symptom score (range 0-35, higher is worse) were identified in univariate and multivariable analyses. Secondary outcomes included AF burden and AF healthcare utilization. We also compared subsequent clinical management at 6 months between patients with better versus worse AF HRQoL.
resultsOverall, 1338 patients completed the AFSS symptom score, which varied by sex (mean 7.26 for males vs. 10.27 for females; p < .001), age (<65, 9.73; 65-74, 7.66; ≥75, 7.58; p < .001), heart failure (9.39 with HF vs. 7.67 without; p < .001), and prior ablation (7.28 with prior ablation vs. 8.84; p < .001). In multivariable analysis, younger age (mean difference 2.92 for <65 vs. ≥75; p < .001), female sex (mean difference 2.57; p < .001), pulmonary disease (mean difference 1.88; p < .001), and depression (mean difference 2.46; p < .001) were associated with higher scores. At 6-months, worse baseline symptom score was associated with the use of rhythm control (37.1% vs. 24.5%; p < .001). Similar cofactors and results were associated with increased AF burden and health care utilization scores.
conclusionsAF PROs in clinical practice identify highly-symptomatic patients, corroborating findings in more controlled, clinical trials. Increased AFSS score correlates with more aggressive clinical management, supporting the utility of disease-specific PROs guiding clinical practice.
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