ArticleThe Journal of physiology2021
Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude.
Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Systematic review and meta-analysis of antioxidant treatment in patients with acute mountain sickness induced by high altitude exposure.Frontiers in physiology · 2026Pooled it
- Effects of the micronutrient Sanopal® (5-hydroxymethyl-2-furfural and α-ketoglutaric acid) on oxygen affinity of hemoglobin, oxygen saturation and exercise responses at altitude.Journal of the International Society of Sports Nutrition · 2026Trial
- Impact of acute sleep restriction on resting ventilation and cytokine levels in normobaric hypoxia, and their association.European journal of applied physiology · 2026Trial
- A new approach to haemoglobin oxygen affinity research at high altitude: Determination of haemoglobin oxygen dissociation curves and 2,3-bisphosphoglycerate in an experimental human crossover hypoxic chamber study.European journal of applied physiology · 2025Trial
- Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension.Pulmonary circulation · 2026Article
- The role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia.The Journal of physiology · 2026Article
- Residence at 1200 m Induces a Threefold Reduction in the Risk of Acute Mountain Sickness After Rapid Ascent to 3600 m.Medicine and science in sports and exercise · 2026Article
- Early acclimatization to high altitude: Acid-base and fluid balance dynamics during the first 2 days at 3100 m.Experimental physiology · 2026Article
- Elevated Hemoglobin Levels and Risk of ST-Segment Elevation Myocardial Infarction in High-Altitude Acute Coronary Syndrome: A Retrospective Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans.Experimental physiology · 2026Article
- On the mechanisms of stress-induced human spleen contraction: training for a higher blood oxygen-carrying capacity.European journal of applied physiology · 2024Review
- Marked hemoglobin mass expansion and plasma volume contraction in Sherpas acclimatizing to 5,400 m altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans.European journal of applied physiology · 2024Article
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- Impact of homeostatic body hydration status, evaluated by hemodynamic measures, on different pain sensitization paths to a chronic pain syndrome.Scientific reports · 2024Article
- Active ascent accelerates the time course but not the overall incidence and severity of acute mountain sickness at 3,600 m.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Changes in body mass, appetite-related hormones, and appetite sensation in women during 4 days of hypobaric hypoxic exposure equivalent to 3,500-m altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women.American journal of physiology. Heart and circulatory physiology · 2022Article
- Effect of hypobaric hypoxia on hematological parameters related to oxygen transport, blood volume and oxygen consumption in adolescent endurance-training athletes.Journal of exercise science and fitness · 2022Article
- Fifteen days of moderate normobaric hypoxia does not affect mitochondrial function, and related genes and proteins, in healthy men.European journal of applied physiology · 2021Article
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Authors and funding
14 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsAcclimatization to hypoxia leads to a reduction in plasma volume (PV) that restores arterial O ABSTRACT: Extended hypoxic exposure reduces plasma volume (PV). The mechanisms underlying this effect are controversial, possibly as previous studies have been confounded by inconsistent experimental conditions. Here, we investigated the effect of hypobaric hypoxia (HH) on PV in a cross-over study that strictly controlled for diet, water intake, physical activity and temperature. Eleven males completed two 4-day sojourns in a hypobaric chamber, one in normoxia (NX) and one in HH equivalent to 3500 m altitude. PV, urine output, volume-regulating hormones and plasma protein concentration were determined daily. Total body water (TBW) was determined at the end of both sojourns by deuterium dilution. Although PV was 8.1 ± 5.8% lower in HH than in NX after 24 h and remained ∼10% lower thereafter (all P < 0.002), no differences were detected in TBW (P = 0.17) or in 24 h urine volumes (all P > 0.23). Plasma renin activity and circulating aldosterone were suppressed in HH during the first half of the sojourn (all P < 0.05) but thereafter similar to NX, whereas no differences were detected for copeptin between sojourns (all P > 0.05). Markers for atrial natriuretic peptide were higher in HH than NX after 30 min (P = 0.001) but lower during the last 2 days (P < 0.001). While plasma protein concentration was similar between sojourns, total circulating protein mass (TCP) was reduced in HH at the same time points as PV (all P < 0.03). Despite transient hormonal changes favouring increased diuresis, HH did not enhance urine output. Instead, the maintained TBW and reduced TCP support an oncotically driven fluid redistribution into the extravascular compartment as the mechanism underlying PV contraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.