Evidence map›Paper›PMID 33124449›Full record

ArticleJournal of diabetes science and technology2022

Five-Year Cost-Effectiveness Modeling of Primary Care-Based, Nonmydriatic Automated Retinal Image Analysis Screening Among Low-Income Patients With Diabetes.

Spencer D Fuller, Jenny Hu, James C Liu, Ella Gibson, Martin Gregory, Jessica Kuo, Rithwick Rajagopal

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Current Trends in AI and Eye Disease Diagnostics.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Artificial intelligence in preventive care in primary health care settings: a scoping review.Archives of medical sciences. Atherosclerotic diseases · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Spencer D FullerJohn F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0001-9371-1140
Jenny HuShiley Eye Institute, University of California San Diego School of Medicine, La Jolla, CA, USA.
James C LiuJohn F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA.
Ella GibsonJohn F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA.
Martin GregoryJohn T. Milliken Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6656-9828
Jessica KuoJohn F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-3591-442X
Rithwick RajagopalJohn F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO, USA.
University of California San Diego · USWashington University in St. Louis · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

backgroundArtificial intelligence-based technology systems offer an alternative solution for diabetic retinopathy (DR) screening compared with standard, in-office dilated eye examinations. We performed a cost-effectiveness analysis of Automated Retinal Image Analysis System (ARIAS)-based DR screening in a primary care medicine clinic that serves a low-income patient population.

methodsA model-based, cost-effectiveness analysis of two DR screening systems was created utilizing data from a recent study comparing adherence rates to follow-up eye care among adults ages 18 or older with a clinical diagnosis of diabetes. In the study, the patients were prescreened with an ARIAS-based, nonmydriatic (undilated), point-of-care tool in the primary care setting and were compared with patients with diabetes who were referred for dilated retinal screening without prescreening, as is the current standard of care. Using a Markov model with microsimulation resulting in a total of 600 000 simulated patient experiences, we calculated the incremental cost-utility ratio (ICUR) of the two screening approaches, with regard to five-year cost-effectiveness of DR screening and treatment of vision-threatening DR.

resultsAt five years, ARIAS-based screening showed similar utility as the standard of care screening systems. However, ARIAS reduced costs by 23.3%, with an ICUR of $258 721.81 comparing the current practice to ARIAS.

conclusionsPrimary care-based ARIAS DR screening is cost-effective when compared with standard of care screening methods.

Indexed as

Diabetes MellitusDiabetic RetinopathyAdolescentAdultArtificial IntelligenceCost-Benefit AnalysisHumansMass ScreeningPrimary Health Careartificial intelligencecost-effectiveness analysisdiabetic retinopathyhealthcare economicsmachine learning technologypublic health

Identifiers

PMID33124449
PMCPMC8861785
OpenAlexW3097024488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.