Evidence map›Paper›PMID 33124432›Full record

ArticleCartilage2021

Consensus on Rehabilitation Guidelines among Orthopedic Surgeons in the United States following Use of Third-Generation Articular Cartilage Repair (MACI) for Treatment of Knee Cartilage Lesions.

David C Flanigan, Seth L Sherman, Brian Chilelli, Wayne Gersoff, Deryk Jones, Cassandra A Lee, Alison Toth, Caryn Cramer, Victor Zaporojan, James Carey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

David C FlaniganDepartment of Orthopedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0001-8876-7043
Seth L ShermanStanford University Medical Center, Redwood City, CA, USA.
Brian ChilelliSports Medicine and Arthroscopy, Cartilage Restoration, Regional Medical Group Orthopaedics, Medical Group Northwestern Medicine, Evanston, IL, USA.
Wayne GersoffAdvanced Orthopedic and Sports Medicine, Orthopedic Centers of Colorado, Denver, CO, USA.
Deryk JonesSports Medicine and Cartilage Restoration, Ochsner Sports Medicine Institute, New Orleans, LA, USA.
Cassandra A LeeDepartment of Orthopedic Surgery, University of California at Davis, Sacramento, CA, USA.
Alison TothDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA.
Caryn CramerVericel Corporation, Cambridge, MA, USA.
Victor ZaporojanVericel Corporation, Cambridge, MA, USA.
James CareyPenn Center for Advanced Cartilage Repair and Osteochondritis Dissecans Treatment, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aastrom Biosciences (United States) · USMinnesota Orthopedic Sports Medicine Institute · USNorth Carolina Central University · USNorthwestern Medicine · USOrthopedic Center · USStanford Medicine · USThe Ohio State University Wexner Medical Center · USUniversity of California, Davis · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate levels of consensus in rehabilitation practices following MACI (autologous cultured chondrocytes on porcine collagen membrane) treatment based on the experience of an expert panel of U.S. orthopedic surgeons.

designA list of 24 questions was devised based on the current MACI rehabilitation protocol, literature review, and discussion with orthopedic surgeons. Known areas of variability were used to establish 4 consensus domains, stratified on lesion location (tibiofemoral [TF] or patellofemoral [PF]), including weightbearing (WB), range of motion (ROM), return to work/daily activities of living, and return to sports. A 3-step Delphi technique was used to establish consensus.

resultsConsensus (>75% agreement) was achieved on all 4 consensus domains. Time to full WB was agreed as immediate (with bracing) for PF patients (dependent on concomitant procedures), and 7 to 9 weeks in TF patients. A progression for ROM was agreed that allowed patients to reach 90° by week 4, with subsequent progression as tolerated. The panel estimated that the time to full ROM would be 7 to 9 weeks on average. A range of time was established for release to activities of daily living, work, and sports, dependent on lesion and patient characteristics.

conclusionsGood consensus was established among a panel of U.S. surgeons for rehabilitation practices following MACI treatment of knee cartilage lesions. The consensus of experts can aid surgeons and patients in the expectations and rehabilitation process as MACI surgery becomes more prevalent in the United States.

Indexed as

Cartilage, ArticularKnee InjuriesOrthopedic SurgeonsActivities of Daily LivingConsensusConsensus Statements as TopicHumansTransplantation, AutologousACIMACIrehabilitationreturn to sportreturn to work

Identifiers

PMID33124432
PMCPMC8808808
OpenAlexW3095184407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.