SynthesisHormones (Athens, Greece)2021
Effect of low-ratio n-6/n-3 PUFA on blood lipid level: a meta-analysis.
Synthesis in Hormones (Athens, Greece), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Dietary Fish Oil and a Flavor and Multi-Enzyme Complex Supplementation Improved the Reproductive Performance, Nutrient Metabolism and Health of Primiparous Lactating Sows and Piglets.Animals : an open access journal from MDPI · 2026Article
- The triglyceride-glucose index, metabolic biomarkers, and olive oil in diabetic patients: Real-world evidence from a propensity-score matched study.Clinics (Sao Paulo, Brazil) · 2025Article
- Maternal supplementation with balanced fatty acid fat powder enhances sow reproductive performance and offspring intestinal health by modulating mitochondrial fusion and cell apoptosis.Frontiers in nutrition · 2025Article
- Effects of n-3 polyunsaturated fatty acids and selenomethionine supplementation on physicochemical properties, oxidative stability and endogenous enzyme activities of fresh pork loin.Food chemistry: X · 2024Article
- Increased Odds of Metabolic Dysfunction-Associated Steatotic Liver Disease Are Linked to Reduced n-6, but Not n-3 Polyunsaturated Fatty Acids in Plasma.Biomolecules · 2024Article
- Efficacy of Chitosan, Pectin and Xanthan as Cold Gelling Agents in Emulsion Gels Stabilized with Legume Proteins to Be Used as Pork Backfat Replacers in Beef Burgers.Gels (Basel, Switzerland) · 2023Article
- The Influence of Lifestyle on High-Density Lipoprotein Concentration among Mexican Emerging Adults.Nutrients · 2023Article
- Effects of Dietary Plant-Derived Low-Ratio Linoleic Acid/Alpha-Linolenic Acid on Blood Lipid Profiles: A Systematic Review and Meta-Analysis.Foods (Basel, Switzerland) · 2023Article
- Determination of Fatty Acid Profile in Processed Fish and Shellfish Foods.Foods (Basel, Switzerland) · 2023Article
- New Advances in Metabolic Syndrome, from Prevention to Treatment: The Role of Diet and Food.Nutrients · 2023Review
- Lipid levels in the Jiarong Tibetan's diet at high altitudes: a cross-sectional survey.Frontiers in nutrition · 2023Article
- New horizons for selenium in animal nutrition and functional foods.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- The function of omega-3 polyunsaturated fatty acids in response to cadmium exposure.Frontiers in immunology · 2022Review
- Effect of cow's milk with different PUFA n-6: n-3 ratios on performance, serum lipid profile, and blood parameters of grower gilts.PloS one · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeThe aim of this meta-analysis was to evaluate the effects of low-ratio n-6/n-3 PUFA on blood lipid levels.
methodsWe searched the PubMed, Embase, and Cochrane Library databases for randomized controlled trials of n-6/n-3 PUFA interventions up to March 2019. The change values were calculated as weighted mean differences (WMDs) by using a random-effect model. Subgroup analysis and meta-regression were used to explore the source of heterogeneity.
resultsA total of 30 randomized controlled trials with 1368 participants were identified. Compared with control, low-ratio n-6/n-3 PUFA significantly reduced triglyceride (TG) concentration (WMD: - 0.079 mmol/L, 95% confidence interval (CI): - 0.148 mmol/L to - 0.009 mmol/L, p = 0.026) and increased high-density lipoprotein cholesterol (HDL-C) concentration (WMD: 0.033 mmol/L, 95% CI: 0.007 to 0.058 mmol/L, p = 0.012). Subgroup analysis revealed that the effects of low-ratio n-6/n-3 PUFA on blood lipid levels were better for a longer time. The effects of α-linolenic acid on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations were more obvious among participants. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) had more significant effects on TG and HDL-C concentrations. No significant publication bias was observed for TG and HDL-C, as suggested by the results of Begg's test and Egger's test.
conclusionLow-ratio n-6/n-3 PUFA significantly reduced TG concentration and increased HDL-C concentration. The beneficial effects of low-ratio n-6/n-3 PUFA on TG, TC, HDL-C, and LDL-C concentrations were enhanced with time. However, n-3 PUFA derived from plants significantly reduced TC and LDL-C concentrations, and n-3 PUFA derived from EPA and DHA significantly reduced TG concentration and increased HDL-C concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.