ArticleCurrent medical science2020
Relationships between Chronic Diseases and Depression among Middle-aged and Elderly People in China: A Prospective Study from CHARLS.
Article in Current medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 2 of them syntheses that pooled it.
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Who cites it
146 citing papers in PubMed, 2 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- Effects of traditional Chinese mind-body exercises on depressive symptoms in middle-aged and older adults: a multilevel meta-analysis with exploratory dose-response and machine learning analyses.Frontiers in psychology · 2026Pooled it
- Effectiveness of Telecare Interventions on Depression Symptoms Among Older Adults: Systematic Review and Meta-Analysis.JMIR mHealth and uHealth · 2024Pooled it
- Longitudinal association between sleep duration and fall risk in middle-aged and older adults: A multiple mediation pathways analysis.Sleep medicine: X · 2026Article
- The Association Between Living Environment and Depression: The Mediating Role of Sleep Duration.Journal of prevention (2022) · 2026Article
- Multimorbidity Clusters and Depressive Symptom Networks in Old Age: Evidence From China.Psychiatry investigation · 2026Article
- Arthritis/Rheumatism and Depressive Symptoms in Middle-Aged and Older Chinese Adults: Regression and Symptom Network Evidence from CHARLS 2018.Healthcare (Basel, Switzerland) · 2026Article
- Depression and increased cancer risk: a 10-year population-based cohort study.Social psychiatry and psychiatric epidemiology · 2026Article
- Explainable Machine Learning Reveals Pattern-Specific Drivers of Depression in Middle-Aged and Older Adults with Multimorbidity: A Nationwide Cross-Sectional Study from CHARLS.Healthcare (Basel, Switzerland) · 2026Article
- Rural-Urban Disparities in the Cognitive Returns to Education Among Chinese Older Adults: A Longitudinal, Causal Robustness, and Mechanism Analysis.Research square · 2026Article
- An explainable geospatial framework for fine-scale Fatty Liver Disease (FLD) risk assessment: roles of social economy, built environment, and psychology.BMC public health · 2026Article
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- Association Between Depressive Symptoms and Risk of New-Onset Chronic Liver Disease Among Middle-Aged and Elderly Chinese Adults: A Prospective Cohort Study Based on the China Health and Retirement Longitudinal Study.Healthcare (Basel, Switzerland) · 2026Article
- Identification of depression types and key influencing factors among rural elderly in China: a comprehensive analysis based on machine learning and network analysis.BMC geriatrics · 2026Article
- Symptom-specific intervention targets for depression and anxiety among older adults by physical multimorbidity patterns: a simulation-based network analysis.Social psychiatry and psychiatric epidemiology · 2026Article
- Association between intrinsic capacity and chronic lung disease among middle-aged and older adults: evidence from CHARLS and ELSA.BMC public health · 2026Article
- The Trajectory of Activities of Daily Living and Its Influencing Factors in Older Adults: A Longitudinal Study.Nursing open · 2026Article
- The interplay of multimorbidity and depressive symptoms: mediation role of functional dependence.Epidemiology and psychiatric sciences · 2026Article
- Identifying depression in middle-aged and older adults stratified by chewing ability using machine learning models: a nationwide cross-sectional study in China.BMC public health · 2026Article
- Urban-rural differences in depressive symptoms and related factors among employed middle-aged and older adults: a national cross-sectional study in China.BMC public health · 2026Article
- A predictive model for depression in Chinese middle-aged and elderly people with arthritis.BMC psychiatry · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the rapid increase in the prevalence of chronic diseases in aging populations, this prospective study including 17 707 adults aged ≥45 years from China Health and Retirement Longitudinal Study was used to estimate the associations between chronic disease, multimorbidity, and depression among middle-aged and elderly adults in China, and explore the mediating factors. Depressive symptoms were assessed using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10) questionnaire. Twelve chronic physical conditions, including hypertension, diabetes, dyslipidemia, cancer, chronic lung disease, liver disease, heart failure, stroke, kidney disease, arthritis or rheumatism, asthma, digestive disease were assessed. The prevalence rates for physical multimorbidity and depression (CES-D-10 ≥10) were 43.23% and 36.62%, respectively. Through multivariable logistic models and generalized estimating equation (GEE) models, we found all 12 chronic physical conditions, and multimorbidity were significantly associated with depression. Both mobility problems and chronic pain explained more than 30% of the association for all chronic conditions, with particularly high percentages for stroke (51.56%) and cancer (51.06%) in mobility problems and cancer (53.35%) in chronic pain. Limited activities of daily living (ADL) explained 34.60% of the stroke-cancer relationship, while sleep problems explained between 10.15% (stroke) and 14.89% (chronic lung disease) of the association. Individuals with chronic diseases or multimorbidity are significantly more likely to be depressed. Functional symptoms involving limitations of ADL and mobility difficulties mediated much of the association between chronic diseases and incident depression. These symptoms could be targeted for interventions to ameliorate the incidence of depression among individuals with chronic conditions.
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