Evidence map›Paper›PMID 33123852›Full record

ArticleLasers in medical science2021

Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier.

Lina Nguyen, Eric O Potma, Jimmy N Le, Julie Johnson, Gabrielle Romena, Qian Peng, Kristian Berg, Henry Hirschberg

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lina NguyenBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA. Linanguyen824@gmail.com.
Eric O PotmaBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
Jimmy N LeBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
Julie JohnsonBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
Gabrielle RomenaBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
Qian PengPathology Clinic, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310, Oslo, Norway.
Kristian BergDepartment of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310, Oslo, Norway.
Henry HirschbergBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd, Irvine, CA, 92617, USA.
Beckman Laser Institute and Medical Clinic · USOslo University Hospital · NOUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibrin glue (FG) has potential as a delivery vehicle for photosensitizer directly to the resection cavity, so it may bypass the blood-brain barrier (BBB) and increase the concentration of successfully delivered photosensitizer. A specialized form of photodynamic therapy (PDT), photochemical internalization (PCI), which involves both photosensitizer and chemotherapeutic agent internalization, can locally inhibit the growth of cells. This will allow the reduction of recurrence of malignant gliomas around surgical resection. This study will look at the efficacy of FG loaded with drugs in mediating both PDT and PCI in inhibiting 3-dimensional tumor spheroid growth in vitro. Experiments were conducted on spheroids comprised of F98 glioma cells using photosensitizer AlPcS

Indexed as

AnimalsAntineoplastic AgentsBiological TransportBleomycinBlood-Brain BarrierCell Line, TumorDrug CarriersFibrin Tissue AdhesiveHumansIndolesLasers, SemiconductorOrganometallic CompoundsPhotosensitizing Agentsaluminum phthalocyanine disulfonateAntineoplastic AgentsBleomycinDrug CarriersFibrin Tissue AdhesiveIndolesOrganometallic CompoundsPhotosensitizing AgentsBleomycinFibrin gluePCIPhotochemical internalization

Identifiers

PMID33123852
OpenAlexW3096156653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.