ReviewCurrent neurology and neuroscience reports2020
Treatment of Epilepsy Associated with Periventricular Nodular Heterotopia.
Review in Current neurology and neuroscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Initial Clinical Experience with the First FDA-Approved sEEG-Guided Radiofrequency Ablation System Featuring Real-Time Temperature Monitoring: A Case Series.Stereotactic and functional neurosurgery · 2026Article
- Brain network characteristics of favorable outcomes following radiofrequency thermocoagulation for drug-resistant epilepsy in periventricular nodular heterotopia patients.BMC neurology · 2026Article
- Involved but not essential: cognitive activity in periventricular nodules and neuropsychological outcomes following their ablation.Journal of neurosurgery · 2025Article
- Reflex "toothbrushing" epilepsy: Seizure freedom after focal ablation assisted by ictal fMRI.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Whether radiofrequency thermocoagulation guided by stereotactic electroencephalography can benefit drug-resistant epilepsy in the early follow-up stage.Acta epileptologica · 2025Article
- Women With Genetic Epilepsies.Neurology. Genetics · 2025Review
- Quantitative proteomics unveils known and previously unrecognized alterations in neuropathic nerves.Journal of neurochemistry · 2024Article
- Article
- Radiofrequency ablation during stereoelectroencephalography: from diagnostic tool to therapeutic intervention. Illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- The phenotypic spectrum of epilepsy associated with periventricular nodular heterotopia.Journal of neurology · 2023Article
- Surgical treatment of epilepsy in a patient with bilateral periventricular nodular heterotopia: A case report.Surgical neurology international · 2023Article
- Review
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewEpilepsy associated with periventricular nodular heterotopia (PNH), a developmental malformation, is frequently drug-resistant and requires focal therapeutic intervention. Invasive EEG study is usually necessary to delineate the epileptogenic zone, but constructing an accurate hypothesis to define an appropriate electrode implantation scheme and the treatment is challenging. This article reviews recent studies that help understanding the epileptogenicity and potential therapeutic options in PNH. RECENT
findingsNew noninvasive diagnostic and intracerebral EEG analytic tools demonstrated that cortical hyperexcitability and aberrant connectivity (between nodules and cortices and among nodules) are likely mechanisms causing epilepsy in most patients. The deeply seated PNH, if epileptogenic, are ideal target for stereotactic ablative techniques, which offer concomitant ablation of multiple regions with relatively satisfactory seizure outcome. Advance in diagnostic and analytic tools have enhanced our understanding of the complex epileptogenicity in PNH. Development in stereotactic ablative techniques now offers promising therapeutic options for these patients.
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