ArticlePediatric surgery international2021
Resection of primary tumor in stage 4S neuroblastoma: a second study by the Italian Neuroblastoma Group.
Article in Pediatric surgery international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Management and Outcomes of Children with Stage 4S (MS) Neuroblastoma: A Single-Center Experience from a Resource-Challenged Nation.Indian journal of pediatrics · 2023Article
- Neuroblastoma Stage 4S (MS): Identification of Risk Factors and Treatment Decisions.Indian journal of pediatrics · 2023Article
- Surgical Advances in Paediatric Neuroblastoma.Children (Basel, Switzerland) · 2022Article
- Metastatic 4S neuroblastoma with excellent outcome in Saudi cancer center.Saudi medical journal · 2021Article
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Authors and funding
18 authors at 7 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo clarify the role of primary tumor resection in stage 4S neuroblastoma.
methodsWe investigated a cohort of 172 infants diagnosed with stage 4S neuroblastoma between 1994 and 2013. Of 160 evaluable patients, 62 underwent upfront resection of the primary tumor and 98 did not.
resultsFive-year progression-free and overall survival were significantly better in those who had undergone upfront surgery (83.6% vs 64.2% and 96.8% vs 85.7%, respectively). One post-operative death and four non-fatal complications occurred in the resection group. Three patients who had not undergone resection died of chemotherapy-related toxicity. Thirteen patients underwent late surgery to remove a residual tumor, without complications: all but one alive. Outcomes were better in patients diagnosed from 2000 onwards.
conclusionInfants diagnosed with stage 4S neuroblastoma who underwent upfront tumor resection had a better outcome. However, this result cannot be definitely attributed to surgery, since these patients were selected on the basis of their favorable presenting features. Although the question of whether to operate or not at disease onset is still unsolved, this study confirms the importance of obtaining enough adequate tumor tissue to enable histological and biological studies to properly address treatment, to achieve the best possible outcome.
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