Observational studyWorld journal of urology2021
The impact of intraoperative bleeding on the risk of chronic kidney disease after nephron-sparing surgery.
Observational study in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Association of PADUA and RENAL scores with early perioperative outcomes in large renal tumors managed with robot-assisted partial nephrectomy.Frontiers in surgery · 2026Article
- Long-term functional outcomes in patients undergoing radical nephrectomy for renal cell carcinoma and tumor thrombus.World journal of urology · 2024Article
- Risk factors and predictive model for acute kidney Injury Transition to acute kidney disease in patients following partial nephrectomy.BMC urology · 2023Article
- Letter to the editor: Development of a simple nomogram to estimate risk for intraoperative complications before partial nephrectomy based on the Mayo Adhesive Probability score combined with the RENAL nephrometry score.Investigative and clinical urology · 2021Article
- Robotic-assisted partial nephrectomy outcomes with airseal® versus conventional insufflation: A single tertiary center comparative study.Therapeutic advances in urologyArticle
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe current literature regarding the effect of blood loss (eBL) after nephron-sparing surgery (NSS) on long-term renal function is scarce. We tested the effect of eBL on the risk of developing chronic kidney disease (CKD) after NSS.
methodsWithin an institutional prospectively maintained database, we identified 215 patients treated with NSS for cT
resultsAfter a median follow-up of 36 months, 55 (25.6%) patients experienced CKD after surgery. At multivariable analyses, eBL independently predicted higher risk of CKD after NSS (odds ratio [OR]: 1.16; 95% confidence intervals [CI] 1.04-1.30; p < 0.01). Specifically, the relationship between eBL and probability of CKD emerged as nonlinear, with a plateau from 0 to 500 mL of eBL and an increase afterward. When multivariable linear regression analyses investigated predictors of eBL, hypertension (Est: 127, 95% CI 12-242; p = 0.03), clinical size (Est: 47, 95% CI 7-87; p = 0.02), and PADUA score (Est: 42; 95% CI 4-80 p = 0.03) achieved independent predictor status for higher intraoperative eBL. Conversely, surgical experience was associated with lower eBL (p = 0.01).
conclusionsIntraoperative bleeding is independently associated with the risk of developing CKD after surgery, even after adjustment for well-known predictors of renal failure and tumor complexity. Hence, strategies aimed at maximally reducing such adverse events deserve special consideration.
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