Evidence map›Paper›PMID 33123732›Full record

ArticleNeuro-oncology2020

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017.

Quinn T Ostrom, Nirav Patil, Gino Cioffi, Kristin Waite, Carol Kruchko, Jill S Barnholtz-Sloan

Erratum issued 2 registry-linked trialsAbstract read
In one paragraph

Article in Neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 1,165 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,165citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06492486 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow

TypeinterventionalSponsorTata Memorial CentreRan2026 to 2028Enrolled60ConditionsDiffuse Glioma, Glioblastoma, Adaptive Radiotherapy, Artificial IntelligenceArmsAdaptive radiotherapy
NCT07243470 phase1 / phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Multicenter, Open-label Phase I/II Trial Aiming to Assess the Safety and Clinical Activity of Tarlatamab in Combination With Metronomic Temozolomide in Adolescents and Adults' Patients With High Grade Brain Tumors

TypeinterventionalSponsorCentre Leon BerardRan2025 to 2030Enrolled70ConditionsGlioma, CNS Tumor, Adult, CNS Tumor, ChildhoodArmsTarlatamab, Temozolomide (TMZ)
3 · Its place in the literature

Who cites it

1,165 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Phosphoproteomic dysregulation promotes tumor proliferation in Cushing's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  6. Review
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  8. Review
  9. Article
  10. Pediatric low-grade glial, glioneuronal and neuronal tumors: a retrospective study of 85 cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  11. Article
  12. Review
  13. Review of promising benzimidazole-based anticancer agents (2023-2026).Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Systemic and local dysregulation of the complement system in glioma: a comprehensive systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  19. Article
  20. Review

1,105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Quinn T OstromCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Nirav PatilCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Gino CioffiCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Kristin WaiteCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Carol KruchkoCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Jill S Barnholtz-SloanCentral Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control (CDC) and National Cancer Institute (NCI), is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors (malignant and non-malignant) and supersedes all previous CBTRUS reports in terms of completeness and accuracy. All rates (incidence and mortality) are age-adjusted using the 2000 US standard population and presented per 100,000 population. The average annual age-adjusted incidence rate (AAAIR) of all malignant and non-malignant brain and other CNS tumors was 23.79 (Malignant AAAIR=7.08, non-Malignant AAAIR=16.71). This rate was higher in females compared to males (26.31 versus 21.09), Blacks compared to Whites (23.88 versus 23.83), and non-Hispanics compared to Hispanics (24.23 versus 21.48). The most commonly occurring malignant brain and other CNS tumor was glioblastoma (14.5% of all tumors), and the most common non-malignant tumor was meningioma (38.3% of all tumors). Glioblastoma was more common in males, and meningioma was more common in females. In children and adolescents (age 0-19 years), the incidence rate of all primary brain and other CNS tumors was 6.14. An estimated 83,830 new cases of malignant and non-malignant brain and other CNS tumors are expected to be diagnosed in the US in 2020 (24,970 malignant and 58,860 non-malignant). There were 81,246 deaths attributed to malignant brain and other CNS tumors between 2013 and 2017. This represents an average annual mortality rate of 4.42. The 5-year relative survival rate following diagnosis of a malignant brain and other CNS tumor was 23.5% and for a non-malignant brain and other CNS tumor was 82.4%.

Indexed as

RegistriesAdolescentAdultAgedBrain NeoplasmsCentral Nervous System NeoplasmsChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleMiddle AgedUnited States

Identifiers

PMID33123732
PMCPMC7596247

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.