ArticleCerebral cortex (New York, N.Y. : 1991)2021
Mapping Progressive Gray Matter Alterations in Early Childhood Autistic Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Unraveling the complex interplay between glymphatic function, age, and brain structure in school-aged children with autism spectrum disorder.Brain imaging and behavior · 2026Article
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth.Frontiers in psychiatry · 2026Article
- Brain Activity Within Prefrontal Cortex: A Resting-State fNIRS Comparative Study in High-Functioning Autism Preschoolers and Typically Developed Peers.Journal of biophotonics · 2025Article
- Anterior Insula Drives Progressive Structural Brain Network Atrophy in the Behavioural Variant of Frontotemporal Dementia.Human brain mapping · 2025Article
- Unraveling morphological brain network disparities Parkinsonian tremor from essential tremor: an artificial intelligence approach for clinical differentiation.NPJ Parkinson's disease · 2025Article
- Sex differences in brain functional specialization and interhemispheric cooperation among children with autism spectrum disorders.Scientific reports · 2024Article
- Social motivation in infancy is associated with familial recurrence of ASD.Development and psychopathology · 2024Article
- Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children.Developmental cognitive neuroscience · 2023Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Understanding the relationship between cerebellar structure and social abilities.Molecular autism · 2023Article
- Mapping brain functional and structural abnormities in autism spectrum disorder: moving toward precision treatment.Psychoradiology · 2022Review
- Basal ganglia atrophy-associated causal structural network degeneration in Parkinson's disease.Human brain mapping · 2022Article
- Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving an umbilical cord blood infusion.Frontiers in psychiatry · 2022Article
- Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder is an early-onset neurodevelopmental condition. This study aimed to investigate the progressive structural alterations in the autistic brain during early childhood. Structural magnetic resonance imaging scans were examined in a cross-sectional sample of 67 autistic children and 63 demographically matched typically developing (TD) children, aged 2-7 years. Voxel-based morphometry and a general linear model were used to ascertain the effects of diagnosis, age, and a diagnosis-by-age interaction on the gray matter volume. Causal structural covariance network analysis was performed to map the interregional influences of brain structural alterations with increasing age. The autism group showed spatially distributed increases in gray matter volume when controlling for age-related effects, compared with TD children. A significant diagnosis-by-age interaction effect was observed in the fusiform face area (FFA, Fpeak = 13.57) and cerebellum/vermis (Fpeak = 12.73). Compared with TD children, the gray matter development of the FFA in autism displayed altered influences on that of the social brain network regions (false discovery rate corrected, P < 0.05). Our findings indicate the atypical neurodevelopment of the FFA in the autistic brain during early childhood and highlight altered developmental effects of this region on the social brain network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.